Overview

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.

Full Product Details

Author:   Ulrich Hubscher (Univ Of Zurich-irchel, Switzerland) ,  Giovanni Maga (Inst Of Molecular Genetics Igm-cnr, Italy) ,  Giuseppe Villani (Cnrs-paul Sabatier Univ, France) ,  Silvio Spadari (Inst Of Molecular Genetics Igm-cnr, Italy)
Publisher:   World Scientific Publishing Co Pte Ltd
Imprint:   World Scientific Publishing Co Pte Ltd
Dimensions:   Width: 16.50cm , Height: 2.00cm , Length: 24.90cm
Weight:   0.771kg
ISBN:  

9789814299169

ISBN 10:   9814299162
Pages:   340
Publication Date:   15 April 2010
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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