Overview

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.

Full Product Details

Author:   Michel Neidhart (Center of Experimental Rheumatology, Centre for Clinical Research, University Hospital, Zurich, Switzerland) ,  Steffen Gay
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 15.20cm , Height: 3.00cm , Length: 22.90cm
Weight:   1.520kg
ISBN:  

9780124201941

ISBN 10:   0124201946
Pages:   552
Publication Date:   20 October 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. DNA methylation – Introduction 2. DNA methylation and epigenetics biomarkers in cancer 3. DNA methylation and epigenetic biomarkers in non-neoplastic diseases 4. DNA methylation and environmental factors 5. DNA methylation and epidemiology 6. DNA methylation and viral infections 7. DNA methylation and cancer 8. DNA methylation in breast and ovarian carcinoma 9. DNA methylation in tumorous multi-drug resistance 10. DNA methylation and endocrinology 11. DNA methylation in metabolic diseases (obesity, type II diabetes) 12. DNA methylation in pituitary diseases 13. DNA methylation and development 14. DNA methylation in growth retardation 15. DNA methylation in cardiology 16. DNA methylation and neurology 17. DNA methylation in psychiatric diseases (schizophrenia, alcohol and drug abuses) 18. DNA methylation in neurodegenerative diseases 19. DNA methylation and autoimmunity 20. DNA methylation in lymphocyte development 21. DNA methylation in stem cell diseases 22. DNA methylation and rheumatology – introduction 23. DNA methylation in synovial fibroblasts 24. DNA methylation in osteoporosis 25. Epigenetic therapies 26. Demethylation agents (5-azacytidine) 27. Methyl donors (s-adenoyl methionine) 28. Methylome analysis of complex diseases 29. Methylome analysis in cancer 30. Methylome analysis in non-neoplastic disease 31. Outlook

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Author Information

Professor Neidhart is a senior scientist at the Center of Experimental Rheumatology, Centre for Clinical Research, Switzerland.

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