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OverviewThis book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments. Full Product DetailsAuthor: Nina Papavasiliou (Rockefeller Univ, Usa) , Sebastian Fugmann (National Inst Of Health, Usa) , Marilyn Diaz (National Inst Of Health, Usa)Publisher: Imperial College Press Imprint: Imperial College Press Volume: 3 Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 22.90cm Weight: 0.576kg ISBN: 9781848165922ISBN 10: 1848165927 Pages: 232 Publication Date: 27 October 2010 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsSwitch Regions, Chromatin Accessibility and AID Targeting; Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Partners in Diversity: The Search for AID Co-Factors; Resolution of AID Lesions in Class Switch Recombination; Error-Prone and Error-Free Resolution of AID Lesions in SHM; Regulatory Mechanisms of AID Function; AID in Immunodeficiency and Cancer; AID in Aging and in Autoimmune Disease.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |