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Overview"Numerous physical and chemical stress factors, endogenous or exogenous, challenge living organisms. Metabolisation processes generate highly reactive intermediates which can covalently bind to DNA, resulting in bulky addition products called ""adducts."" DNA adduct formation appears to be a general response of plants to organic chemical exposure, whether in controlled conditions or in the field. In particular, common carcinogenic pollutants and pesticides promote the formation of DNA adducts in plants. The authors of this book examine the development of DNA adducts, as well as the ways in which they can be eliminated due to DNA repair pathways. In this book, the data from in vivo transgenic assays is also examined, which can help to clarify specific pre-mutagenic adducts, DNA repair functions and mutational events that may be involved in the mutagenicity of human carcinogens. Other chapters in this book identify and discuss novel anthracyclines capable of forming DNA adducts, the role of DNA adducts as early biomarkers in the screening and development of marine anticancer drugs, the genotoxicity, such as DNA adduct formation, of air pollutants and its assessment by in vivo mutagenesis and a discussion of oxidative DNA damage, which can play an important role in the carcinogenic processes of PAHs and aromatic amines, in addition to bulky-DNA adducts formation." Full Product DetailsAuthor: Emerson Álvarez , Roberto CunhaPublisher: Nova Science Publishers Inc Imprint: Nova Science Publishers Inc Dimensions: Width: 26.00cm , Height: 2.00cm , Length: 18.00cm Weight: 0.464kg ISBN: 9781607414339ISBN 10: 1607414333 Pages: 232 Publication Date: 20 May 2010 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Awaiting stock  The supplier is currently out of stock of this item. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out for you. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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