Overview

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Full Product Details

Author:   M. Celeste Simon ,  M Celeste Simon
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2010 ed.
Volume:   345
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.435kg
ISBN:  

9783642133282

ISBN 10:   3642133282
Pages:   146
Publication Date:   05 September 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

The HIF-2?-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization.- Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance.- Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression.- The Role of Hypoxia Regulated microRNAs in Cancer.- Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration.- Hypoxia-Inducible Factors as Essential Regulators of Inflammation.- Hypoxia and Metastasis in Breast Cancer.

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