Overview

The studies described here were carried out in the Neuroregul­ ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the last decade, this group, in close collaboration with the Department of Neurosurgery of the Academic Hospital of Leiden, has studied the development of the central nervous system from a neuroanatomical as well as a clinical perspective. During this period, the expression of several morphore­ gulators in the developing rat spinal cord was extensively investigated. Parallel studies focused on the development of the spinal cord fiber systems, which was studied by means of the intrauterine use of neuronal tracers. The main goal of these studies was to extend our knowledge about the (normal) generation of the spinal cord and to contribute to the under­ standing of clinical problems related to regeneration and degeneration in the mammalian central nervous system. The studies on morphoregulators, in particular, appeared to benefit two different scientific areas. Firstly, the correlation between morphoregulator expression patterns and known anatomy contributed to our knowledge about spinal cord development. Secondly, the correlation between morpho regulator expression patterns and known developmental processes may help to understand their precise function(s). This volume of Advances in Anatomy, Embryology and Cell Biology presents these particular studies on the development of the rat spinal cord performed over the last decade. As well as integrating the results of the tracer studies, this volume also provides an update on the development of the rat spinal cord.

Full Product Details

Author:   Martin F. Bach ,  Egbert A.J.F. Lakke ,  Enrico Marani ,  Raph T.W.M. Thomeer
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   129
Dimensions:   Width: 17.00cm , Height: 1.00cm , Length: 24.20cm
Weight:   0.340kg
ISBN:  

9783540571735

ISBN 10:   3540571736
Pages:   166
Publication Date:   20 December 1993
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1 Introduction.- 2 A Survey of the Development of the Rat Spinal Cord.- 2.1 The Matrix Layer.- 2.2 The Mantle Layer.- 2.3 The Marginal Layer.- 2.4 Development of Descending Fiber Tracts.- 3 Materials and Methods.- 3.1 Animals.- 3.2 Histological Procedures.- 3.3 Antibodies.- 3.4 Immunohistochemistry.- 3.5 Enzyme Histochemistry.- 3.6 Neuronal Tracing: Intrauterine and Postnatal Applications.- 4 Results.- 4.1 General Comments on the Techniques.- 4.2 Matrix Layer.- 4.3 Mantle Layer.- 4.4 Marginal Layer.- 4.5 Tracer Experiments.- 5 Discussion.- 5.1 Matrix Layer.- 5.2 Mantle Layer.- 5.3 Marginal Layer.- 5.4 Development of Long Descending Systems.- 6 New Insights into the Development of the Rat Spinal Cord.- 6.1 Matrix Layer.- 6.2 Mantle Layer.- 6.3 Marginal Layer.- 7 Summary.- 7.1 Matrix Layer.- 7.2 Mantle Layer.- 7.3 Marginal Layer.- References.

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