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OverviewPolycystic ovarian syndrome is a common condition affecting 5-10% of women of childbearing age. This disorder is probably the most common hormonal abnormality in women of reproductive age. In 95% of women with PCOS, an ultrasound of the ovaries will reveal cysts that can be seen on the surface of the ovary. Most of researchers found the evidence that INSR gene show consistent; linkage and association with PCOS. The INSR receptor gene comprises 22 exons spanning 120kb on chromosome 19. Mutations in exon 17 and intron 13, 8 that encode the tyrosine kinase domain of the insulin receptor. Mutations in exon 17 and intron 13, 8 that encode the tyrosine kinase domain of the insulin receptor, have been shown severe insulin resistance and hyperinsulinemia. Two possible approaches are used to identify a genetic locus for PCOS genes: (i) association studies where a predisposing allele is expected to be found more frequently in the affected population than the normal individuals and (ii) linkage studies where the probands and their families are investigated to determined if particular genomics landmarks are distributed independently or in linkage with the phenotype. Full Product DetailsAuthor: H Mohammad Noor , A Al- Kazaz Abdul KareemPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.70cm , Length: 22.90cm Weight: 0.186kg ISBN: 9783659709937ISBN 10: 365970993 Pages: 120 Publication Date: 11 May 2015 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |