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OverviewThis work combines biochemical studies, structural biology investigations and small molecule design within some of the protein classes that play major roles in signal transduction: the protein kinases, the growth factor family and the transcription factors. It describes how these proteins communicate with each other via different signalling pathways. Three-dimensional structures of these proteins are presented, and their interaction with small molecules and co-factors are described. The use of these proteins for pharmaceutical research and the design of small molecules and their selectivity towards such proteins are discussed. Full Product DetailsAuthor: Ilme Schlichting , Ursula EgnerPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Volume: v. 34 Weight: 0.420kg ISBN: 9783540414940ISBN 10: 3540414940 Pages: 222 Publication Date: 15 May 2001 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Temporarily unavailable  The supplier advises that this item is temporarily unavailable. It will be ordered for you and placed on backorder. Once it does come back in stock, we will ship it out to you. Table of ContentsC.-H. Heldin: Regulation of Kinases by Growth Factors; E.A. Nigg: Cell Cycle Regulation by Protein Kinases and Phosphatases; L. Johnson: Structural Basis of Substrate Recognition and Control by Protein Kinases; A. Levitzki: The Selectivity of Small Molecules Towards Protein Tyrosine Kinases; H.H. Grunicke et al.: Elements of Signal Transduction in Drug Discovery with Special Reference to Inhibitors of Protein Kinase C; U. Heinemann: The Berlin Protein Structure Factory Initiative: A Technology-Based Approach to Structural Genomics; F.K. Winkler et al.: Structure-Based Approaches in Modern Drug Discovery Research; C.W. Muller: DNA Recognition by NFkB and STAT Transcription Factors; J.-M. Wurtz, D. Moras: Molecular Determinants for Agonists and Antagonist Binding to Steroid Nuclear Receptors; J.D. Norris et al.: Estrogen Receptor-Cofactor Interactions as Target for Novel Drug Discovery.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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