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OverviewCytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research,to clinical presentations, risk factors, and treatment. Full Product DetailsAuthor: Randy Q. Cron , Edward M. BehrensPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2019 Weight: 1.118kg ISBN: 9783030220938ISBN 10: 3030220931 Pages: 617 Publication Date: 20 September 2019 Audience: Professional and scholarly , Professional & Vocational Replaced By: 9783031598142 Format: Hardback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsReviewsAuthor InformationRandy Q. Cron, MD, PhD University of Alabama at Birmingham Professor of Pediatrics and Medicine Birmingham Alabama USA Edward M. Behrens, MD University of Pennsylvania Perelman School of Medicine Perelman School of Medicine Philadelphia Pennsylvania USA Tab Content 6Author Website:Countries AvailableAll regions |