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OverviewFull Product DetailsAuthor: Costas Ioannides (University of Surrey, UK) , Diana Anderson , Xinxin Ding , Graeme MurrayPublisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Volume: Volume 3 Dimensions: Width: 15.60cm , Height: 3.30cm , Length: 23.40cm Weight: 0.972kg ISBN: 9780854042746ISBN 10: 0854042741 Pages: 544 Publication Date: 27 June 2008 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviews<p>Xenobiotic Metabolism<p>Cytochromes P450. Role in the metabolism and toxicity of drugs and other xenobiotics <br>Costas Ioannides<br>Cambridge, UK, RSC Publishing 2008 - 400pp - (HB) ISBN 9780854042746 <p>Reviewed by Paul R Ortiz de Montellano <p>This book is intended for postgraduate students and professionals interested in the toxicological consequences of the metabolism of drugs and xenobiotics by cytochrome P450 enzymes. <br>Although an introductory chapter provides general background on the cytochrome P450 system, most of the book addresses the roles of these enzymes in toxicology, with a central core of chapters in which the roles of the individual P450 families are surveyed. The organic and mechanistic chemistry of the reactions is sporadically discussed, but the book's strength is its biochemical and toxicological focus. <br>The approach of reviewing the cytochrome P450 system and its role in drug activation, followed by discussion of the roles of the individual P4 Xenobiotic Metabolism <p>Cytochromes P450. Role in the metabolism and toxicity of drugs and other xenobiotics <br>Costas Ioannides<br>Cambridge, UK, RSC Publishing 2008 ] 400pp ] (HB) ISBN 9780854042746 <p>Reviewed by Paul R Ortiz de Montellano <p>This book is intended for postgraduate students and professionals interested in the toxicological consequences of the metabolism of drugs and xenobiotics by cytochrome P450 enzymes. <br>Although an introductory chapter provides general background on the cytochrome P450 system, most of the book addresses the roles of these enzymes in toxicology, with a central core of chapters in which the roles of the individual P450 families are surveyed. The organic and mechanistic chemistry of the reactions is sporadically discussed, but the book's strength is its biochemical and toxicological focus. <br>The approach of reviewing the cytochrome P450 system and its role in drug activation, followed by discussion of the roles of the individual P450 families, and finishing with aspects of regulation is effective. However, the coverage is selective rather than comprehensive. Thus, one finds an extended discussion of the use of modeling in substrate predictions, but only a brief survey of the principles of enzyme inactivation. Likewise, the activation of polycyclic aromatic hydrocarbons is extensively reviewed, but other activation reactions, such as those of alkyl halides heterocyclic rings, are essentially not discussed. Most surprisingly, the prototypical oxidation of acetaminophen to a hepatotoxic species is not covered in any detail. <br>Despite its shortcomings, this book provides a readable, up-to-date review of the critical roles ofcytochrome P450 enzymes in all areas of toxicology. As such, it fills a void in the current review literature and will be welcomed by investigators interested in the contribution of oxidative xenobiotic metabolism to xenobiotic and drug toxicity. <p>Chemistry World. 2008. 5(10), p.p.75 """In summary, this monograph within the Issues in Toxiciology series is a highly informative and competent as well as stimulating account on our current knowledge in CYPology and will be an excellent orientation especially for young researchers entering the field"" Toxicology ""this book provides a readable, up-to-date review of the critical roles of cytochrome P450 enzymes in all areas of toxicology. As such, it fills a void in the current review literature..."" Chemistry World, Reviewed by Paul R. Ortiz de Montellano, October Issue" In summary, this monograph within the Issues in Toxiciology series is a highly informative and competent as well as stimulating account on our current knowledge in CYPology and will be an excellent orientation especially for young researchers entering the field Toxicology this book provides a readable, up-to-date review of the critical roles of cytochrome P450 enzymes in all areas of toxicology. As such, it fills a void in the current review literature... Chemistry World, Reviewed by Paul R. Ortiz de Montellano, October Issue Author InformationCostas Ioannides, BSc (University of Liverpool), PhD (University of Surrey), DSc (University of Liverpool) is currently Professor of Mechanistic Toxicology at the University of Surrey and is an established author in this area. Tab Content 6Author Website:Countries AvailableAll regions |
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