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OverviewShowcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling. Full Product DetailsAuthor: Xiaodong Cheng (University of Texas Health Science Center, Houston, USA)Publisher: Taylor & Francis Ltd Imprint: CRC Press Weight: 0.412kg ISBN: 9780367658809ISBN 10: 0367658801 Pages: 288 Publication Date: 30 March 2021 Audience: College/higher education , General/trade , Tertiary & Higher Education , General Format: Paperback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsCompartmentalization of cyclic nucleotide signaling. Analysis of EPAC-mediated cAMP functions in cell communication. Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways. Discovery of small molecule EPAC specific modulators. Adenylyl cyclase and A kinase-anchoring proteins in cardiovascular physiology and pathology. Cyclic nucleotide recognition and selectivity. Real-time intracellular imaging of cGMP. Dissecting cyclic nucleotide signalosomes by chemical proteomics. Cyclic nucleotide analogs as chemical tools for interaction analyses. cAMP signaling in pancreatic ß cells. Quantitative high throughput cAMP assay for G-protein coupled receptors. Quantitative proteomics analysis of the cAMP signaling pathway. Network analysis of cyclic nucleotide signaling. Evolution and functional diversity of cyclic nucleotide binding domains. X-ray crystallographic analysis of cyclic nucleotide activated protein kinases. Dissect physiological functions of PKA isoforms using genetically modified mouse models. Assessing cyclic nucleotide binding domain allostery by NMR analysis. Fluorescence resonance energy transfer (FRET) imaging of cyclic nucleotide in live cells. Structural and functional analyses of exchange protein directly activated by cAMP. Structural analysis of PKA: strategies for therapeutic intervention. Monitoring cyclic nucleotide signaling using genetically encoded fluorescent reporters.ReviewsAuthor InformationCheng, Xiaodong Tab Content 6Author Website:Countries AvailableAll regions |