Overview

A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.

Full Product Details

Author:   Alexey S. Kondrashov
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Dimensions:   Width: 16.50cm , Height: 1.50cm , Length: 23.90cm
Weight:   0.249kg
ISBN:  

9781118952115

ISBN 10:   1118952111
Pages:   304
Publication Date:   04 July 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface ix 1 Genotypes and Phenotypes 1 1.1 DNA is a Text 1 1.2 Genomes Small and Large 6 1.3 Genes and Intergenic Regions 7 1.4 Cells, Mitosis, and Meiosis 14 1.5 From Genotype to Phenotype 17 Further Reading 21 2 Mendelian Inheritance and Population Genetics 23 2.1 Inheritance is Discrete 23 2.2 Populations are Genetically Variable 27 2.3 Loci and Genes 33 2.4 Effects of Alleles on Phenotypes 37 2.5 Mendelian Traits and Diseases 43 Further Reading 46 3 Complex Traits and Their Inheritance 49 3.1 Complex Inheritance of Phenotypes 49 3.2 Properties of a Complex Trait 52 3.3 Complex Traits in Populations 55 3.4 Effects of Heredity and Environment on Complex Traits 60 3.5 Polymorphic Loci Behind Complex Variation 64 Further Reading 68 4 Unavoidable Mutation 71 4.1 Phenomenon of Mutation 71 4.2 Kinds of Mutations 73 4.3 Spontaneous Mutation 75 4.4 Evolution of Mutation Rates 77 4.5 Artificial Mutagenesis and Antimutagenesis 79 Further Reading 81 5 Struggle for Fidelity 83 5.1 Fidelity of DNA Replication 83 5.2 Cleaning Up After the Replisome 88 5.3 Dealing with DNA Damages 91 5.4 Harms of Broken Maintenance 96 5.5 Mechanisms of Mutation 100 Further Reading 104 6 Mutation Rates 107 6.1 Measuring Mutation Rates 107 6.2 Data on Mutation Rates 109 6.3 Guilty Older Men 112 6.4 Rates of Phenotypically Drastic Mutations 114 6.5 Mild Mutations and Mutational Pressures 118 Further Reading 121 7 Natural Selection 123 7.1 Vulnerable Adaptations and Their Evolutionary Origin 123 7.2 Two Basic Characteristics of Selection 127 7.3 Measuring Natural Selection 129 7.4 Selection at a Polymorphic Locus 132 7.5 Selection on a Quantitative Trait 135 Further Reading 138 8 Functioning DNA and Junk DNA 141 8.1 Selective Neutrality and Random Drift 141 8.2 Effective Population Size 144 8.3 Junk DNA Provides the Simplest Evidence for Evolution 144 8.4 Finding Functioning Genome Segments 145 8.5 The Genomic Rate of Deleterious Mutations 147 Further Reading 148 9 It Takes All the Running You Can Do 149 9.1 Middle Class Neighborhood for Drosophila 149 9.2 Selection Against Deleterious Alleles 153 9.3 Mutation–Selection Equilibrium 155 9.4 Inbreeding Depression 158 9.5 Dangerous Slightly Deleterious Alleles 160 Further Reading 162 10 Phenomenon of Imperfection 165 10.1 Phenotypic and Genotypic Imperfection 165 10.2 Five Evolutionary Causes of Imperfection 168 10.3 Weakly Perfect Human Genotypes and Phenotypes 171 10.4 Native, Novel, and Optimal Environments 173 10.5 Factors, Exacerbating Mutation Imperfection 175 Further Reading 176 11 Our Imperfect Fitness 177 11.1 Properties of an Allele 177 11.2 Human Derived Alleles 180 11.3 Average Imperfection of a Genotype 186 11.4 Variation Among Genotypes 190 11.5 Selection in Modern Human Populations 192 Further Reading 197 12 Our Imperfect Wellness 199 12.1 Qualitative Characteristics of Wellness 199 12.2 Quantitative Traits 206 12.3 Contributions of Heredity and Environment 208 12.4 Wellness‐impairing Alleles 211 12.5 Genetic Architecture of Wellness 215 Further Reading 217 13 Mutational Pressure on Our Species 219 13.1 Mutational Pressure on Diseases 219 13.2 Mutational Pressure on Quantitative Traits 225 13.3 Possible Increase of the Mutational Pressure 226 13.4 De Novo Mutations and Human Wellness 228 13.5 Optimistic and Pessimistic Scenarios 230 Further Reading 231 14 Ethical Issues 233 14.1 Lessons from History 233 14.2 Modern Practices 237 14.3 Humanist Ethics and the Main Concern 241 14.4 The Main Concern and Ethical Dilemmas 244 14.5 Role of Scientists 247 Further Reading 250 15 What to Do? 253 15.1 Conditionally Beneficial or Unconditionally Deleterious? 253 15.2 Mutationless Utopia: What Could It Be? 257 15.3 Mutationless Utopia: Is It Ever Going to Happen? 261 15.4 What Can I Do Without Germline Genotype Modification? 265 15.5 Prognosis 268 Further Reading 269 Index 271

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Author Information

Alexey S. Kondrashov, PhD is Professor of Ecology and Evolutionary Biology at the University of Michigan, Ann Arbor. His research interests include evolution of sex and genetic recombination, properties of spontaneous deleterious mutations and of selection against them, and dynamics of genetic variation in natural and artificial populations.

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