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OverviewThis book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions. Full Product DetailsAuthor: Roger Traub, MD (Research Staff Member, Physical Sciences Dept., Research Staff Member, Physical Sciences Dept., IBM T.J. Watson Research Center) , Miles Whittington, PhD (Professor of neuroscience, Institute of Neuroscience, Professor of neuroscience, Institute of Neuroscience, ION, The Medical School, Newcastle University)Publisher: Oxford University Press Inc Imprint: Oxford University Press Inc Dimensions: Width: 23.60cm , Height: 3.60cm , Length: 16.30cm Weight: 0.771kg ISBN: 9780195342796ISBN 10: 0195342798 Pages: 448 Publication Date: 03 June 2010 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Out of Stock Indefinitely Availability: In Print  Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock. Table of ContentsReviews<br> Traub and Whittington's Cortical Oscillations in Health and Disease is a tour de force presentation of one of the pivotal concepts in modern neuroscience: the dynamic electrical organization of the brain's cortical mantle. Its treatment of the role of oscillatory coherence in the organization of temporal binding, based on the intrinsic neuronal properties and their recurrent connectivity, is masterful. The breadth and depth of this treatise is as impressive as is the insight into function offered by these two outstanding scientists. <br>--Rodolfo R. Llinas MD, PhD, Chairman and Professor, Department of Physiology and Neuroscience New York University School of Medicine New York, NY <br> Brain oscillations are an essential component of normal brain function but they also show key and sometimes pathognomonic alterations during brain disease. This monograph presents a thorough review of the advances made over the last 10 years in the understanding of the cellular mechanismsE <br> Traub and Whittington's Cortical Oscillations in Health and Disease is a tour de force presentation of one of the pivotal concepts in modern neuroscience: the dynamic electrical organization of the brain's cortical mantle. Its treatment of the role of oscillatory coherence in the organization of temporal binding, based on the intrinsic neuronal properties and their recurrent connectivity, is masterful. The breadth and depth of this treatise is as impressive as is the insight into function offered by these two outstanding scientists. <br>--Rodolfo R. Llin s MD, PhD, Chairman and Professor, Department of Physiology and Neuroscience New York University School of Medicine New York, NY <br><p><br> Brain oscillations are an essential component of normal brain function but they also show key and sometimes pathognomonic alterations during brain disease. This monograph presents a thorough review of the advances made over the last 10 years in the understanding of the cellular mechanisms of various types of brain oscillations. Building largely on the vast body of experimental and computational work developed by the authors themselves, the book presents an insightful and critical review of the relevance of network oscillations in understanding major neuropsychiatric conditions such as parkinson's disease, schizophrenia and epilepsy. The book is written with sufficient detail as to be an essential read to scientists and clinicians but not hopeless to the non expert. <br>--Diego Contreras, MD, PhD, Dept of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA <br><p><br> The authors combine their enthusiasm for the subject with tremendous insight, resulting in a brilliant text suitable for a broad audience. A broad historical introduction draws in young scientists who know little about brain oscillations. This is followed by an in depth discussion of the significant developments in the field over the last ten years. The authors illustrate h <br> Traub and Whittington's Cortical Oscillations in Health and Disease is a tour de force presentation of one of the pivotal concepts in modern neuroscience: the dynamic electrical organization of the brain's cortical mantle. Its treatment of the role of oscillatory coherence in the organization of temporal binding, based on the intrinsic neuronal properties and their recurrent connectivity, is masterful. The breadth and depth of this treatise is as impressive as is the insight into function offered by these two outstanding scientists. <br>--Rodolfo R. Llinas MD, PhD, Chairman and Professor, Department of Physiology and Neuroscience New York University School of Medicine New York, NY <br> Brain oscillations are an essential component of normal brain function but they also show key and sometimes pathognomonic alterations during brain disease. This monograph presents a thorough review of the advances made over the last 10 years in the understanding of the cellular mechanismss <br> Traub and Whittington's Cortical Oscillations in Health and Disease is a tour de force presentation of one of the pivotal concepts in modern neuroscience: the dynamic electrical organization of the brain's cortical mantle. Its treatment of the role of oscillatory coherence in the organization of temporal binding, based on the intrinsic neuronal properties and their recurrent connectivity, is masterful. The breadth and depth of this treatise is as impressive as is the insight into function offered by these two outstanding scientists. <br>--Rodolfo R. Llin?'s MD, PhD, Chairman and Professor, Department of Physiology and Neuroscience New York University School of Medicine New York, NY <br><p><br> Brain oscillations are an essential component of normal brain function but they also show key and sometimes pathognomonic alterations during brain disease. This monograph presents a thorough review of the advances made over the last 10 years in the understanding of the cellular mechanis Author InformationDr. Traub was educated in mathematics at Princeton, and medicine and neurology at U Penn and Columbia, respectively. He is a founder of the field of detailed modeling of neuronal networks, and has applied this type of modeling to the study of brain oscillations and epilepsy, collaborating closely with Dr. Whittington since the early 1990s. Dr. Whittington was educated in pharmacology at Bristol University. He stayed in Bristol to study mechanisms of alcohol withdrawal-induced hyperexcitability before moving to St Mary's Hospital in London to study more general forms of epileptic activity, where he began working with Dr. Traub. He is founder in the field of in vitro models of EEG oscillations and continues to use these models, coupled with computational approaches, to attempt to understand the basic operational mode of human neocortex. 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