Overview

The cerebral neocortex, a structure unique to the mammalian brain and prerequisite for higher cognitive functions, has since decades attracted the curiosity of neurobiologists and developmental biologists alike. This volume gives a comprehensive and up-to-date overview of early cortical development. It provides concise information on the birth, specification, migration and terminal differentiation of neocortical cells. Both the cellular and molecular events leading to the establishment of a functional neocortex are presented in considerable detail, and possible implications for neurodegenerative diseases are discussed.

Full Product Details

Author:   Christine F. Hohmann
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2002 ed.
Volume:   39
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.508kg
ISBN:  

9783540434368

ISBN 10:   3540434364
Pages:   181
Publication Date:   14 August 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Population Dynamics During Cell Proliferation and Neuronogenesis in the Developing Murine Neocortex.- References.- Mechanisms Regulating Lineage Diversity During Mammalian Cerebral Cortical Neurogenesis and Gliogenesis.- 1 Stem Cell Biology and Neural Development.- 2 Neural Lineage Elaboration and Bone Morphogenetic Proteins.- 3 Environmental and Transcriptional Regulation of Intermediate Progenitor Species.- 4 Mechanisms Regulating Neuronal and Astroglial Lineage Elaboration.- 5 Developmental Regulation and Lineage Potential of Radial Glia.- 6 Biology of Glial-Restricted Progenitors and the Generation of Oligodendrocytes.- 7 Role of ID Genes and Proteins in BMP-Mediated Cerebral Cortical Neural Fate Decisions.- 8 ID Genes and Proteins.- 9 Summary and Future Directions.- References.- Gap Junctions and Their Implications for Neurogenesis and Maturation of Synaptic Circuitry in the Developing Neocortex.- 1 Introduction.- 2 Expression of Gap Junctions in the Neocortex.- 3 Modulation of Gap Junction Permeability During Early Postnatal Stages of Neocortical Development.- 4 Functional Implications of Gap Junctions in the Developing Neocortex.- 5 Concluding Remarks.- References.- Influence of Radial Glia and Cajal-Retzius Cells in Neuronal Migration.- 1 Radial Glial Cells.- 2 Cajal-Retzius Cells and Reelin.- 3 MAM Model.- 4 What Prevents the Normal Laminar Pattern in E24 MAM-Treated Cortex?.- 5 Is There a Radialization Factor in Normal P) Cortex?.- 6 Summary and Conclusions.- References.- Neurotrophins and Cortical Development.- 1 Introduction.- 2 Distribution of the Neurotrophins and Their Receptors.- 3 Regulation of Synaptic Plasticity by the Neurotrophins.- 4 Neurotrophins and Structural Synaptic Plasticity.- 5 Concluding Remarks.- References.- Role of Immediate Early GeneExpression in Cortical Morphogenesis and Plasticity.- 1 Neural Activity Plays a Critical Role in the Development of the Cerebral Cortex.- 2 Learning and Development Share Mechanisms of Neural Plasticity.- 3 Molecular Events Underlying Cortical Plasticity: the Immediate Early Gene Response.- 4 Effector Neuronal Immediate Early Genes.- 5 Conclusions.- References.- Role of Afferent Activity in the Development of Cortical Specification.- 1 Introduction.- 2 Sensory Modalities: Vision and Audition.- 3 Intrinsic Determination of Modality-Specific Subregions of Cortex.- 4 A Role for Extrinsic Inputs in Specification of Local Cortical Networks.- References.- Regional Forebrain Patterning and Neural Subtype Specification: Implications for Cerebral Cortical Functional Connectivity and the Pathogenesis of Neurodegenerative Diseases.- 1 Introduction.- 2 Role of the Ventral Telencephalon in Cerebral Cortical Development.- 3 Developmental Actions of Neurogenic bHLH Genes.- 4 Mechanisms Regulating the Transition from Neurogenesis to Gliogenesis.- 5 Olig Genes and Regional Shh Signaling.- 6 Importance of Regional Forebrain Patterning for Neural Subtype Specification.- 7 Role of Local BMP Signaling in Cerebral Cortical Neuronal and OL Lineage Elaboration.- 8 Generation of OL Lineage Species in the Adult Brain: Therapeutic Implications.- 9 Role of Gap Junction Channels and GABAergic Neuronal Subtypes in Cerebral Cortical Functional Connectivity.- 10 Regional Forebrain Patterning and Neurodegenerative Diseases.- 11 Summary and Future Directions.- References.

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