Overview

The genetics of schizophrenia have taken the driver seat in the research - lated to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide pat- physiological scenarios that could link those cellular phenomena with sy- toms. In this book, we have chosen to elaborate on that link. The contributions to this book have been requested to reflect the current state of the connection between schizophrenia genetics and pathophysiology. The book opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes.

Full Product Details

Author:   Patricio O'Donnell
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2008 ed.
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   0.397kg
ISBN:  

9781489993045

ISBN 10:   1489993045
Pages:   239
Publication Date:   12 September 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms.- Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function.- Homer: A Genetic Factor in Schizophrenia?.- Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia.- Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia.- A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia.- Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia.- Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications.- Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses.- Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences.- Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology.

Reviews

From the reviews: Cortical Deficits in Schizophrenia: From Genes to Function is an important contribution to the literature on schizophrenic syndrome analysis. It also can serve as an excellent model of productive interdisciplinary collaboration. Clinical as well as basic scientific specialists from a very wide variety of disciplines who share a common interest in schizophrenic syndrome analysis will find much new information in this work that is insightful, original, and exceptionally well integrated. (James A. Moses, PsycCRITIQUES, Vol. 34 (3), August, 2008)

From the reviews: Cortical Deficits in Schizophrenia: From Genes to Function is an important contribution to the literature on schizophrenic syndrome analysis. It also can serve as an excellent model of productive interdisciplinary collaboration. Clinical as well as basic scientific specialists from a very wide variety of disciplines who share a common interest in schizophrenic syndrome analysis will find much new information in this work that is insightful, original, and exceptionally well integrated. (James A. Moses, PsycCRITIQUES, Vol. 34 (3), August, 2008)

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