Overview

This book examines key theoretical tools that are currently used to develop mathematical models as an aid in understanding the biological response of cells and tissues to mechanical stimuli. Problems in growth and remodeling, tissue and organ development, and functional adaptation are all covered. Chapters on tensor analysis and nonlinear elasticity provide the necessary background for understanding the engineering theories that are currently used to solve challenges in mechanobiology. This is an ideal book for biomechanical engineers who work on problems in mechanobiology and tissue engineering.

Full Product Details

Author:   Larry A. Taber
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2020
Weight:   1.093kg
ISBN:  

9783030432072

ISBN 10:   3030432076
Pages:   535
Publication Date:   16 June 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Introduction.- Vectors and tensors.- Coordinate transformation.- Tensor invariants.- Special tensors.- Vector and tensor calculus.- Nonlinear Elasticity.- Kinematics.- Stress.- Balance principles.- Constitutive equations.- Boundary value problems.- Active Force Generation.- Muscle contraction.- Concept of changing zero-stress state.- Cardiac mechanics: time-varying elastance.- Stress fibers.- Cell division.- Growth.- Growth theory.- Growth of arteries.- Growth of the heart.- Growth of tumors.- Growth of plants.- Remodeling.- Remodeling theory.- Remodeling of arteries.- Aneurysms.- Cytoskeletal remodeling.- Bone remodeling (Wolff’s law).- Morphogenesis.- Fundamental developmental processes.- Modeling morphogenesis.- Pattern formation.- Gastrulation.- Head fold formation.- Neurulation.- Brain development.- Primary vesicle formation.- Cortical folding.- Eye development.- Heart development.- Cardiac looping.- Gut development.- Wound healing.- Plant morphogenesis.- Mechanical feedback in development.

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Author Information

Larry Taber is a Senior Professor of Biomedical Engineering at Washington University in St. Louis. From 2007 until his retirement in 2017, he was the Dennis and Barbara Kessler Professor of Biomedical Engineering. Although his formal training is in aerospace engineering (B.A.E., Georgia Tech; Ph.D., Stanford University), he has published on a wide range of topics including cochlear mechanics, nonlinear shell theory, cardiovascular mechanics, and the mechanics of growth and development. Dr. Taber is a fellow of the American Society of Mechanical Engineers (ASME) and the American Institute for Medical and Biological Engineering. Three times he won the Richard Skalak Award for the best paper published in the Journal of Biomechanical Engineering, and in 2020 was awarded the H.R. LIssner Medal from ASME. From 2011-2016, he served as co-editor-in-chief of the journal Biomechanics and Modeling in Mechanobiology.

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