Overview

Diverse technologies have emerged in recent times to streamline applications of more predictable materials and methods, in order to attain the elusive goal of periodontal regeneration. Their applications, current limitations and future directions are reviewed. In addition to grafting materials and barrier membranes to exclude epithelial downgrowth and promote mesenchymal elements, the environment of the cell is pivotal to events that follow. These include application of scaffolds, lasers, harnessing bone anabolic activity and the resolution of inflammation using cell-and gene-based protein and peptide therapy. Recommendations embrace suitable targets for patient outcome based on clinical applications of scientific principles for more predictable and consistent results in regenerating hard and soft tissues of a functional periodontium. They must, however, stay within safety requirements and an effective cost/benefit ratio. Regenerative medicine and dentistry combine applications of molecular biology, material science, bioengineering and nanoscience in order to repair, regenerate and replace missing tissue. The author discusses these applications as well as the mechanisms that modulate cells and matrices in periodontal regeneration as well as regenerative medicine.

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9781634829700

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Mena Soory is a clinical academic in Periodontology. Activities encompass teaching the specialty in a clinical and academic setting, including curriculum planning and development of undergraduate courses, examination at undergraduate and postgraduate levels; and is a Fellow of the Higher Education Academy, UK. The main areas of clinical and research interest are in the fields of Relevance of redox status in periodontitis and associated systemic diseases; mechanisms involved, Disease mechanisms linking periodontitis and prevalent systemic diseases, Nutritional antioxidants and their significance in periodontal and systemic diseases and Periodontal regenerative methods, materials and mechanisms applicable to regenerative medicine. Mena Soory has acted as principal supervisor of over a dozen theses. These activities have generated nearly 200 peer reviewed publications, congress presentations, books and book chapters; including a themed journal supplement as guest editor. She is actively engaged in 5 editorial boards of international journals; and in the activities of the British Society of Peridontology, European Federation of Periodontology, International Academy of Periodontology, British Society for Oral and Dental Research, International Association for Dental Research and the Endocrine Society.

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