Overview

Building from the perspective of reproductive and developmental biology, this book provides a timely and comprehensive overview of computational approaches in reproductive and developmental toxicology. It is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in

Full Product Details

Author:   Donald R. Mattison ,  James Devillers (CTIS, Rillieux La Pape, France)
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 2.30cm , Length: 23.40cm
Weight:   0.657kg
ISBN:  

9781439861073

ISBN 10:   1439861072
Pages:   330
Publication Date:   08 December 2015
Audience:   Professional and scholarly ,  General/trade ,  Professional & Vocational ,  General
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of Pregnancy. Early Embryo Development and Bipotential Gonad Formation. Assessing the Reproductive Health of Men with Occupational Exposures. REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity. US National Library of Medicine Resources for Computational Toxicology. Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations. Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver Injury. Adverse Outcome Pathways for Developmental Toxicity.

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Author Information

Donald R. Mattison is Senior Advisor to the Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

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