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Ov r the ur of 6-8 g n r t n , but ll n the l t 2-3 g n r t n , th r has b n an epidemic of b t nd n n- nf t u d g n r t v d kn wn v l z t n d . Wh l infectious g nt w r th major causes of d at th beginning f the 20th ntur , nf t u d w r r l d by type 2 d b t mellitus (T2DM) nd d b t complications, rd v ul r d (CVD) and cancer as major causes of death by the 21 t century. At r nt, westernized ul t n r plagued b a plethora f hr n degenerative diseases, n lud ng b t , T2DM, atherosclerosis, r n r h rt disease, stroke, ut mmun d , nt l hypertension, n r, osteoporosis nd th r more, nd th number f th d l rapidly increasing in d v l ng countries. In tr k ng contrast, obesity nd v l z t n diseases are rare or virtually absent n hunter-gatherer (HG) nd other non-westernized ul t n . Al , l w rum n ul n l v l nd r t ntl excellent n ul n n t v t r characteristic f HG, but nl l ng as th l dh r to th r traditional paleolithic d t .Oth rw , transition to a W t rn diet (WD, as d f n d below) invariably leads t a dr m t n r n n ul n resistance (IR) (defined h r n impaired b l t f th h rm n t suppress h t glucose output nd t promote r h r l glucose d l) nd hyperinsulinemia as w ll as b t , T2DM, h rt n n, n r nd th r m r . On the other hand, a r turn t a tr d t n l paleolithic d t is associated w th m rk d m r v m nt in IR nd f t ng insulin l v l 5 nd glu ntr l nd lipid r f l f T2DM..The common counter-argument th t St n Ag r u u ll d n t l v long enough to d v l degenerative diseases n t accurate. A conspectus of d t n HG t suggests th t modal g of dult d th is b ut v n decades (adaptive life span f 68-78 years). In ntr t t most W t rn r , these l tend t b h lth up t old g . C u of d th are predominantly nf t u d , wh l hr n d g n r t v d rd r r r r .

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