Overview

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Full Product Details

Author:   Saverio Bettuzzi ,  Sabina Pucci
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   105
Dimensions:   Width: 15.20cm , Height: 1.50cm , Length: 22.90cm
Weight:   0.470kg
ISBN:  

9780123814296

ISBN 10:   0123814294
Pages:   350
Publication Date:   24 November 2009
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

"1.    CLU and prostate cancer. S. Bettuzzi and F. Rizzi 2.    The role of Clusterin (CLU) in malignant transformation and drug resistance in breast carcinomas Maximino Redondo; Teresa Tellez; María Jose Roldan. 3.    CLU and COLON CANCER The dual face of CLU: from normal to malignant phenotype Mazzarelli P. Pucci S. Spagnoli L.G. 4.    Clusterin (CLU) and lung cancer F. Panico*, 2F. Rizzi*, 1L.M. Fabbri, and 2S. Bettuzzi°, 1F. Luppi° 5.    CLUSTERIN AND CHEMORESISTANCE Julie Y. Djeu and Sheng Wei 6.    CLU ""in and out"": looking for a link Pucci S.1 , Mazzarelli P. 1 , Nucci C. 2, Ricci F. 2, Spagnoli L.G. 1 7. Regulation of CLU gene expression by oncogenes and epigenetic factors: Implications for tumorigenesis Arturo Sala, 2 * Saverio Bettuzzi, 3 Sabina Pucci, 1 Olesya Chayka, 4 Michael Dews, and 4 Andrei Thomas-Tikhonenko 8. CONCLUSIONS AND PERSPECTIVES Saverio Bettuzzi"

Reviews

This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences. -- American Scientist Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced. -- Journal of Medicinal Chemistry This is a series that has a long tradition of excellence in the field of cancer biology. -- Doody's Publishing Reviews

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