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OverviewNon-isotopic in situ hybridization (NISH) methods are increasingly employed to analyze unique chromosomal abnormalities and gene rearrangements, and for physical mapping of DNA sequences on chromosomes. The techniques are also useful tools for prenatal diagnosis of major chromosomal disorders. This volume provides comprehensive coverage of the methodology and its relevance to the molecular investigation of selected inherited diseases. It describes the principle of the printed in situ hybridization (PRINS) technique and documents the clinical applications of both NISH and PRINS, through the analysis of chromosomes in metaphase of interphase, particularly in patients with abnormalities that cannot be detected by conventional methods. In addition, it discusses the use of NISH and PRINS for the prenatal diagnosis of chromosomal abnormalities in foetal cells in interphase, and the use of NISH to study chromosomal abnormalities in solid tumours using the comparative genomic hybridization (CGH) method and somatic cell hybrids. Full Product DetailsAuthor: Matteo Adinolfi , Angela F. DaviesPublisher: Taylor & Francis Inc Imprint: CRC Press Inc Weight: 0.522kg ISBN: 9781879702851ISBN 10: 1879702851 Pages: 114 Publication Date: 01 January 1994 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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