Overview

Circadian System, Volume 137 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters that comprehensively cover Circadian Systems Genes and Their Importance for Human Health, Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on Gene Function and Phenotype, Relationship between circadian rhythm and diseases: sex hormones impact, Advances in circadian clock regulation of reproduction, Disruption of the clock gene expression in central and peripheral circadian oscillators by maternal overnutrition in the Oryctolagus cuniculus, COVID-19 disease management in aspect of Circadian system, and more. Other sections cover Molecular Characterization of Circadian Gene Expression and Its Correlation with Survival Percentage in Colorectal Cancer Patients, Identifying circadian gene signature that estimates overall survival from colon adenocarcinoma, The role of environmental signals in the expression of rhythmic cardiac proteins and their influence on cardiac pathologies, and much more.

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Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

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