Overview

This text presents a concise account of modern cytogenetics. Basic facts are presented together with illustrative examples from plant, animal and medical cytogenetics. Selected references guide the reader to recent literature. The book emphasizes the revitalization of cytogenetics resulting from research into the human genome and the subject's integration with molecular biology. Classic cytogenetics is also discussed to give context to more recent studies. This book should be of interest to geneticists, cell biologists, molecular biologists, and students on undergraduate courses in a range of disciplines, medical and life science courses.

Full Product Details

Author:   M. Clark ,  W. Wall
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   1996 ed.
Weight:   1.177kg
ISBN:  

9780412752100

ISBN 10:   0412752107
Pages:   346
Publication Date:   30 June 1996
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Chromatin structure and replication.- 1.1 Chromosome structure.- 1.2 Evidence that DNA is the genetic material.- 1.3 The double helix.- 1.4 The genetic code.- 1.5 DNA constitution.- 1.6 Higher order structure of DNA.- 1.7 Chromosome replication.- 2 Chromosome form and function.- 2.1 Structures in a chromosome.- 2.2 Heterochromatin.- 2.3 Telomeres.- 2.4 Centromeres and kinetochores.- 2.5 Nucleolar organizing regions.- 2.6 Lampbrush and polytene chromosomes.- 2.7 Double minutes and homogeneously staining regions.- 2.8 B chromosomes.- 2.9 Supernumerary segments.- 2.10 Artificial chromosomes.- 3 Chromosome identification.- 3.1 The karyotype.- 3.2 Chromosome banding.- 4 Nuclear division.- 4.1 Mitosis.- 4.2 The spindle apparatus.- 4.3 Meiosis.- 4.4 Chromosome pairing.- 4.5 Synaptonemal complex formation.- 4.6 Recombination nodules.- 4.7 Recombination and gene conversion.- 4.8 Meiosis in polyploids and structural rearrangements.- 4.9 Structural changes.- 5 Gene control by position and origin.- 5.1 Chromosome organization within the nucleus.- 5.2 Chromosomal imprinting.- 6 Mutagenesis.- 6.1 General ideas about mutagenesis.- 6.2 Changes associated with the environment.- 6.3 Chromosomal aberrations.- 6.4 Aneuploidies.- 6.5 Mutations affecting cell proliferation.- 6.6 Translocations.- 6.7 Fragile sites.- 6.8 Transposable elements.- 7 Chromosome mapping.- 7.1 Introduction.- 7.2 Genetic maps.- 7.3 Cytological maps.- 7.4 Correlation between genetic and cytological/physical maps.- 7.5 Mapping strategies.- 8 Sex chromosome systems.- 8.1 Heteromorphic sex chromosome systems.- 8.2 Mammalian sex chromosome systems.- 8.3 X inactivation.- 8.4 Mammalian sex chromosome evolution.- 8.5 Other sex chromosome systems.- 9 Evolution and speciation.- 9.1 Hybrids and cultivars.- 9.2 Speciation by karyotype changes.- 9.3 Speciation in an ancient mammalian group.- 9.4 Evolution of the hominids.- 10 Artificial manipulation of genomes.- 10.1 Manipulation of whole chromosome sets.- 10.2 Manipulationof single chromosomes.- 10.3 Manipulation producing variable genome changes.- 10.4 Single-gene transfer.- 11 Historical aspects of cytogenetics.

Reviews

...an excellent introduction to cytogenetics covering chromosome structure and function, cell division, evolution, mutation, sex chromosome systems, and the artificial manipulation of genomes, with the emphasis on eukaryotes. - Aslib Book Guide; ...clear written style...accessible for the student audience...recommended as a reference... - The Biologist

...an excellent introduction to cytogenetics covering chromosome structure and function, cell division, evolution, mutation, sex chromosome systems, and the artificial manipulation of genomes, with the emphasis on eukaryotes. - Aslib Book Guide; ...clear written style...accessible for the student audience...recommended as a reference... - The Biologist

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