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OverviewChromosomes in humans occasionally break and an exchange, inversion or other more complex rearrangement of the broken pieces can occur. If the breakage causes no damage to essential gene function, and if no overall loss of chromosome material takes place, these rearrangements can remain undetected in healthy carriers. Problems occur when cell division, involving rearranged chromosomes in the germ line, leads to an unbalanced distribution of chromosomal material in the resulting gametes. Depending on how much chromosomal material is involved, the imbalance can cause fertility problems to severe birth defects in the offspring. This book describes a study attempting to identify hot spots for breakage on human chromosomes, in a search for clues to the origin of constitutional chromosome rearrangements. Identifying true hot spots is complicated by ascertainment bias which comes about frequently due to the often severe phenotypic manifestations of chromosome rearrangements. Through accounting for the various sources of bias, a number of candidates for constitutional chromosome rearrangement hot spots are identified. Full Product DetailsAuthor: Krisztina VasarhelyiPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.80cm , Length: 22.90cm Weight: 0.213kg ISBN: 9783844334920ISBN 10: 3844334920 Pages: 140 Publication Date: 31 May 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |