Overview

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.

Full Product Details

Author:   Tommaso Angelone ,  Maria Carmela Cerra ,  Bruno Tota
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Weight:   0.583kg
ISBN:  

9783319863818

ISBN 10:   3319863819
Pages:   267
Publication Date:   05 September 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chromaffin cells and Granins: History and Perspectives.- The extended granin family: structure, function, and biomedical implications.- CgA and CgB in granule secretion.- Proteolytic processing of CgA and CgB/Antimicrobial properties of Chromogranins.- Chromogranins and inositol 1,4,5-trisphosphate-dependent Ca2+-signaling.- CgA in angiogenesis and tumor biology.- Full lenght CgA: a multifaceted protein in cardiovascular health and disease.- Physio-pharmacological aspects of three Chromogranin A-derived peptides: Vasostatin, Catestatin, and Serpinin.- Comparative aspects of CgA-derived peptides in cardiac homeostasis.- Molecular and cellular mechanisms of action of CgA-derived peptides in cardiomyocytes and endothelial cells.- CgA-derived peptides in pre- and post-conditioning cardioprotection.- Catestatin in physiopathology.- Serpinin: from biosynthesis to cell biology and physiopathology.- Pancreastatin and metabolism.- Chromogranins and the quantum release of catecholamines.

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