Overview

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.

Full Product Details

Author:   Anita Göndör (Assistant Professor, Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska Institutet, Solna, Sweden) ,  Anita Gondor
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 19.10cm , Height: 2.80cm , Length: 23.50cm
Weight:   1.180kg
ISBN:  

9780128033951

ISBN 10:   0128033959
Pages:   496
Publication Date:   11 November 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

1. Dynamics and function of DNA methylation during development 2. Histone modifications in pluripotency and differentiation 3. ATP-dependent Chromatin remodelling: from early development to cancer 4. Regulation of cellular identity by Polycomb and Trithorax proteins 5. Crosstalk between chromatin marks at regulatory elements 6. Chromatin modifications and transcriptional noise in cell fate decision 7. Chromatin dynamics during the cell cycle 8. Chromatin dynamics and DNA repair 9. Epigenetic regulation of replication and replication timing 10. Interplay between chromatin and splicing 11. Nuclear lipids and the regulation of chromatin 12. Nuclear architecture and epigenetic memories: Heterochromatin formation in development, senescence and cancer 13.  Noncoding RNAs and the third dimension of the epigenome 14.  Epigenetic control of the nucleolus 15. X chromosome inactivation in 3D 16. Telomere maintenance in the dynamic nuclear architecture 17. Interaction between cellular metabolic states and chromatin dynamics 18. Circadian plasticity of the epigenome 19. The epigenome at the gene-environment interface in complex disease

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Author Information

Dr. Göndör is an Assistant Professor in the Department of Microbiology, Tumor, and Cell Biology (MTC) at Karolinska Institutet. Dr. Göndör is highly motivated to integrate novel aspects of chromatin regulation and nuclear architecture with an emphasis on translational aspects and links to multifactorial human diseases.

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