Chemogenomics: Methods and Applications

Author:   Edgar Jacoby
Publisher:   Humana Press Inc.
Edition:   2009 ed.
Volume:   575
ISBN:  

9781607612735


Pages:   320
Publication Date:   17 September 2009
Format:   Hardback
Availability:   In Print   Availability explained
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Chemogenomics: Methods and Applications


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Overview

Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment, analysis, prediction, and expansion of a comprehensive ligand–target SAR (structure–activity relationship) matrix has followed the elucidation of the human genome and presents a key scientific challenge for the twenty-first century. The anno- tion and knowledge-based exploration of the ligand–target SAR matrix is then expected to impact science greatly. Progress alongside this challenge without a doubt will c- tribute to further the fundamental understanding of the biological function of the individual proteins and ultimately provide a basis for the discovery of new and better therapies for diseases. While historically the chemogenomics approach is based on efforts that systematically explore target gene families, today broader in vitro and in silico approaches are available to encompass wider genomes. In this book, experts from academia and industry outline relevant aspects of ch- istry, biology, and molecular informatics which are the cornerstones of chemogenomics. General introductory chapters are combined with chapters describing methods and pro- cols, which are the gold standard of the Methods in Molecular Biology book series.

Full Product Details

Author:   Edgar Jacoby
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2009 ed.
Volume:   575
Dimensions:   Width: 19.30cm , Height: 2.50cm , Length: 26.00cm
Weight:   0.997kg
ISBN:  

9781607612735


ISBN 10:   1607612739
Pages:   320
Publication Date:   17 September 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Organizing Bioactive Compound Discovery in Target Families.- Compound Library Design for Target Families.- Targeting the Purinome.- Cofactor Chemogenomics.- Chemogenomics with Protein Secondary-Structure Mimetics.- Database Systems for Knowledge-Based Discovery.- Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein–Protein Interaction.- Off-Target Networks Derived from Ligand Set Similarity.- Chemogenomic Analysis of Safety Profiling Data.- Network and Pathway Analysis of Compound–Protein Interactions.- The Flexible Pocketome Engine for Structural Chemogenomics.- Structure-Based Chemogenomics: Analysis of Protein Family Landscapes.- Hypothesis-Driven Screening.

Reviews

From the reviews: Provide practical and authoritative reviews on current research topics. ... The present book represents an illustrative compendium of up-to-date chemogenomics, with a strong emphasis on bio- and cheminformatic concepts. ... It therefore represents a valuable complement to published books that are more 'chemical biology' driven. It is of particular interest for the 'data miners' of the chemogenomics community, giving them an authoritative overview of current technologies and methods available throughout industry and academia. (Markus Kaiser, ChemBioChem, Vol. 11, March, 2010)


From the reviews: Provide practical and authoritative reviews on current research topics. ! The present book represents an illustrative compendium of up-to-date chemogenomics, with a strong emphasis on bio- and cheminformatic concepts. ! It therefore represents a valuable complement to published books that are more 'chemical biology' driven. It is of particular interest for the 'data miners' of the chemogenomics community, giving them an authoritative overview of current technologies and methods available throughout industry and academia. (Markus Kaiser, ChemBioChem, Vol. 11, March, 2010)


From the reviews: “Provide practical and authoritative reviews on current research topics. … The present book represents an illustrative compendium of up-to-date chemogenomics, with a strong emphasis on bio- and cheminformatic concepts. … It therefore represents a valuable complement to published books that are more ‘chemical biology’ driven. It is of particular interest for the ‘data miners’ of the chemogenomics community, giving them an authoritative overview of current technologies and methods available throughout industry and academia.” (Markus Kaiser, ChemBioChem, Vol. 11, March, 2010)


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