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OverviewFull Product DetailsAuthor: V.K. Ahluwalia , Lalita S. Kumar , Sanjiv KumarPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2022 Weight: 0.599kg ISBN: 9783030866976ISBN 10: 3030866971 Pages: 243 Publication Date: 02 December 2022 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsCHAPTER -1: AMINO ACIDS1.1 INTRODUCTION1.2 NOMENCLATURE OF AMINO ACIDS1.2.1 Representation of Amino Acids1.3 CLASSIFICATION OF AMINO ACIDS1.3.1 Coded or Primary Protein Amino Acids1.3.1.1 Nonpolar or Apolar Amino Acids1.3.1.2 Neutral or Uncharged Polar Amino Acids1.3.1.3 Charged Polar Amino Acids 1.3.2 Secondary and Tertiary Protein Amino Acids1.3.3 Non-Coded or Non-Protein Amino Acids1.3.4 Essential Amino Acids 1.4 STEREOCHEMICAL ASPECTS OF a- AMINO ACIDS1.4.1 Absolute Configuration of a-Amino Acids1.4.1.1 The RS Notation 1.4.2 Amino Acids with Two Chiral Centres 1.5 PHYSICAL PROPERTIES OF a-AMINO ACIDS 1.5.1 General Physical Properties 1.5.2 Acid-Base Properties of Amino Acids 1.5.2.1 Amino Acids with Non-Ionisable Side Chains1.5.2.2 Amino Acids with Ionisable Side Chains1.5.3 Spectral Properties of a-Amino Acids1.5.3.1 Mass Spectrometry1.5.3.2 Nuclear Magnetic Resonance (NMR) Spectroscopy1.5.3.3 UV Spectroscopy1.5.3.4 IR Spectroscopy1.5.3.4 Circular Dichroism (CD)CONTENTSviii Chemistry of Natural Products1.6 CHEMICAL REACTIONS OF AMINO ACIDS1.6.1 Reactions due to Amino Group1.6.2 Reactions due to Carboxyl Group1.6.3 Reactions due to both Amino and Carboxyl Groups1.7 INDUSTRIAL PREPARATION OF a-AMINO ACIDS1.8 CHEMICAL SYNTHESIS OF a-AMINO ACIDS1.8.1 Enantiomeric Resolution of a-Amino Acids1.8.2 Asymmetric Synthesis of a-Amino Acids1.9 INDUSTRIAL AP PLICATIONS OF a-AMINO ACIDSExercisesCHAPTER -2 : PEPTIDES2.1 INTRODUCTION2.2 STRUCTURE AND CLASSIFICATION OF PEPTIDES2.2.1 Structure of Peptide Bond2.2.2 Classification of Peptides2.3 NOMENCLATURE OF PEPTIDES2.3.1 Representation of Peptides and Polypeptides2.4 PEPTIDE SYNTHESIS2.4.1 Protection of Amino Group2.4.2 Protection of Carboxyl Group2.4.3 Protection of Side Chains2.4.4 Coupling Methods2.5 SOLID PHASE PEPTIDE SYNTHESIS2.5.1 Solid Phase Peptide Synthesis usingt-Boc Protection (Merrifield Approach) 2.5.2 Solid Phase Peptide Synthesis usingFmoc Protection (Sheppard’s Approach)2.5.3 Limitations of Solid Phase Peptide Synthesis 2.6 SOME BIOLOGICALLY IMPORTANT PEPTIDES 2.6.1 Oxytocin ix Amino Acids2.6.2 Glutathione 2.6.2.1 Role of Glutathione in Disulphide Bond Formation2.6.2.2 Role of Glutathione as an Antioxidant 2.6.3 Insulin 2.6.3.1 Structure Determination of Insulin 2.6.4 Bradykinin 2.6.5 Gramicidin Exercises CHAPTER -3: PROTEINS3.1 INTRODUCTION 3.2 CLASSIFICATION OF PROTEINS 3.2.1 Classification on the Basis of Shape and Structure 3.2.2 Classification on the Basis of Products of Hydrolysis 3.2.3 Classification on the Basis of Biological Functions 3.3 PROPERTIES OF PROTEINS 3.3.1 Molecular Weight 3.3.2 Amphoteric Nature 3.3.3 Solubility 3.3.4 Precipitation 3.3.5 Denaturation 3.3.6 Colour Reactions 3.4 STRUCTURAL ORGANISATION OF PROTEINS 3.4.1 Covalent or Primary Structure of Proteins 3.4.1.1 Amino Acid Composition of Proteins 3.4.1.2 Amino Acid Sequence of Polypeptides 3.4.2 Conformational Aspects of Proteins: Higher Order Structures 3.4.2.1 Secondary Structure of Proteins 3.4.2.2 Tertiary Structure of Proteins 3.4.2.3 Quaternary Structure of Proteins Exercises CHAPTER - 4: ENZYMES4.1 INTRODUCTION x Chemistry of Natural Products4.2 NOMENCLATURE AND CLASSIFICATION OF ENZYMES 4.2.1 Systematic and Recommended Names 4.2.2 Classification Numbers and Code Names 4.3 CHARACTERISTICS OF ENZYMES 4.3.1 Catalytic Power 4.3.2 Enzyme Specificity 4.3.3 Enzyme Regulation4.4MECHANISM OF ENZYME ACTION 4.5 FACTORS AFFECTING ENZYME ACTION 4.6 CHYMOTRYPSIN: AN ENZYME IN ACTION 4.6.1 Structure of Chymotrypsin 4.6.2 Important Amino Acid Residues of Chymotrypsin 4.6.3 Mechanism of Action 4.7 COFACTORS (or COENZYMES) 4.7.1 Nicotinamide Adenine Dinucleotide (NAD+) andNicotinamide Adenine Dinucleotide Phosphate (NADP+) 4.7.2 UDP-Glucose 4.7.3 Flavin Mononucleotide (FMN) and FlavinAdenine Dinucleotide (FAD) 4.7.4 Thiamine Pyrophosphate (TPP) 4.7.5 CoCarboxylase 4.7.6 Pyridoxal-5-Phosphate 4.8 ENZYMES IN ORGANIC SYNTHESIS 4.8.1 Enzymatic Oxidations 4.8.2 Enzymatic Hydroxylation 4.8.3 Enzymatic Hydrolysis 4.8.4 Enzymatic Reductions 4.8.5 Enzymatic Isomerisations 4.6.6 Pharmaceutical Applications of Enzymes Exercises GlossaryIndexReviewsAuthor InformationV.K. Ahluwalia has worked as professor of chemistry, University of Delhi, Delhi for more than three decades and taught postgraduate and M.Phil students. He has guided about 80 students for M.Phil/Ph.D degrees and has published more than 250 research papers in National and International Journals. He has delivered a number of invited lectures in India and Abroad. Prof. Ahluwalia worked as post-doctoral fellow for two years (1960-1962) and worked with Prof. Harold Shechter at the Department of Chemistry Ohio State University, Ohio USA and for one year (1980-81) with Professor Herbert C. Brown, Nobel Laureate at the Department of Chemistry, Purdue University, USA. He has also been a visiting professor at Dr. B.R. Ambedkar Centre for Biomedical Research University of Delhi, Delhi. Prof. Ahluwalia has authored many books a few of which are, Reaction Mechanism, Environmental Chemistry, Environmental Science, Environment Education, Environmental Pollution and Health and Organic Synthesis. His Book on Green Chemistry is the winner 2009 Choice award, being the outstanding academic title. Lalita. S. Kumar did her PhD from University of Delhi in the year 1987 in the area of Synthetic Organic Chemistry. She has five publications to her credit. She is working as Reader at Indira Gandhi National Open University (IGNOU), New Delhi. She has been associated with design, development and maintenance of distance teaching material for over sixteen years. Her areas of interest are biochemistry, organic reaction mechanism and environmental chemistry. Sanjiv Kumar did his PhD from University of Delhi in the year 1990 in the area of biophysical chemistry for which he worked on interaction of peptides and proteins with nuclear acids. He is working as Reader at Deshbandhu College, University of Delhi, and has a teaching experience of over sixteen years. His areas of interest are biochemistry, spectroscopy and quantum chemistry. Tab Content 6Author Website:Countries AvailableAll regions |
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