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OverviewAddresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides. Full Product DetailsAuthor: Joseph J. Stephanos , Anthony W. AddisonPublisher: John Wiley & Sons Inc Imprint: John Wiley & Sons Inc Dimensions: Width: 15.80cm , Height: 2.50cm , Length: 23.60cm Weight: 0.653kg ISBN: 9781118470442ISBN 10: 1118470443 Pages: 448 Publication Date: 16 September 2014 Audience: Professional and scholarly , Professional & Vocational Replaced By: 9781118510148 Format: Paperback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsPreface ix 1 Introduction 1 Proteins: Formation, Structures, and Metalloproteins, 4 References, 28 2 Alkali and Alkaline Earth Cations 31 References, 67 3 Nonredox Metalloenzymes 71 Carboxypeptidases, 75 Carbonic Anhydrase, 84 Alcohol Dehydrogenase, 88 References, 91 4 Copper Proteins 95 Introduction, 95 Electronic Spectra of Copper Ions, 96 ESR Spectra of Copper Ions, 105 Copper Proteins, 117 Plastocyanin, 119 Azurin and Stellacyanin, 127 Superoxide Dismutase, 131 Hemocyanin, 135 Ascorbic Oxidase, 139 References, 142 5 Iron Proteins 147 Introduction, 147 Electronic Spectra of Iron Ions, 148 Mössbauer Spectroscopy of Iron Ions, 155 ESR Spectra of Iron (III), 161 Iron Bioavailability, 166 Siderophores, 171 Iron Storage and Transfer Proteins, 184 Ferritin, 184 Transferrin, 187 Dioxygenase Iron Proteins, 195 Iron–Sulfur Proteins, 207 Rubredoxin, 207 Ferredoxins, 212 2Fe–2S Ferredoxins, 212 4Fe–4S Ferredoxins, 221 Aconitase, 226 Hydroxylases, 229 Hydrogenases, 232 Nitrogenases, 240 Binuclear Iron Proteins, 251 Hemerythrin, 253 Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260 Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267 Myoglobin and Hemoglobin, 275 Myoglobin, 275 Hemoglobin, 280 Cytochrome C, 298 Electron Transfer in Porphyrins and Metalloporphyrins, 301 Catalases, 311 Peroxidases, 315 Cytochrome P-450, 322 Electronic Spectra of Hemoproteins, 327 ESR Spectra of Hemoproteins, 362 References, 378 6 Vitamin B12 393 References, 405 7 Chlorophyll 407 References, 421 Index 423ReviewsAuthor InformationJOSEPH J. STEPHANOS, PHD, is Associate Professor of Bioinorganic, Biophysical, and Inorganic Chemistry at Menofia University. His research examines metalloprotein chemistry, ligand-binding, and coordination chemistry of biologically active compounds. ANTHONY W. ADDISON, PHD, is Professor of Inorganic Chemistry at Drexel University. His research focuses on bioinorganic chemistry; chemistry of dioxygen- and NO-binding metalloproteins; and the design, synthesis, and properties of novel chelating agents and macrocyclic and oligonuclear metal complexes. His numerous research articles and conference presentations have earned over 8,000 citations and a Hirsch Index of 37. Tab Content 6Author Website:Countries AvailableAll regions |
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