Overview

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Full Product Details

Author:   Larry J. Anderson ,  Barney S. Graham
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   372
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   0.869kg
ISBN:  

9783662521557

ISBN 10:   3662521555
Pages:   409
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I  Virology,  Pathogenesis, and Clinical and Epidemiological Features of Disease   Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease Peter L. Collins, Rachel Fearns, and Barney S. Graham   Clinical and Epidemiologic Features of Respiratory Syncytial Virus Caroline B. Hall, Eric A. F. Simőes, and Larry J. Anderson   Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity José A. Melero and Martin L. Moore   Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins Jason S. McLellan, William C. Ray and Mark E. Peeples   Respiratory Syncytial Virus and Reactive Airway Disease Matthew T. Lotz, Martin L. Moore, and R. Stokes Peebles, Jr.     Part II  Host Response to Infection and Genetics of Disease   Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches Eun Hwa Choi, Hoan Jong Lee, and Stephen J. Chanock   Innate Immune Responses to Respiratory Syncytial Virus Infection Sumanta Mukherjee and Nicholas W. Lukacs   The Adaptive Immune Response to Respiratory Syncytial Virus Steven. M. Varga and Thomas J. Braciale   Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons Sailen Barik   Host Gene Expression and Respiratory Syncytial Virus Infection Ralph A. Tripp, Asuncion Mejias, and Octavio Ramilo   Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus Allison M.W. Malloy, Ann R. Falsey, and Tracy J. Ruckwardt   Part III  Vaccine Platforms and Treatment Options   Respiratory Syncytial Virus Disease:  Prevention and Treatment Helen Y.  Chu and Janet A. Englund   Live-Attenuated Respiratory Syncytial Virus Vaccines Ruth A. Karron, Ursula J. Buchholz, and Peter L. Collins   Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus Trudy G. Morrison and Edward E. Walsh   Gene-Based Vaccine Approaches for Respiratory Syncytial Virus Rebecca J. Loomis and Philip R. Johnson Part IV  Animal and Tissue Culture Models of Infection Bovine Model of Respiratory Syncytial Virus Infection Geraldine Taylor   The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection Marina S. Boukhvalova and Jorge C.G. Blanco   The Mouse Model of Respiratory Syncytial Virus Disease Peter J. Openshaw   Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection Raymond J. Pickles   Part V  Conclusions   Challenges and Opportunities for Respiratory Syncytial Virus Vaccines Barney S. Graham and Larry J. Anderson  

Reviews

From the reviews: “I enjoyed the book: as an immunologist who has spent 10 years working on RSV there were a number of novel insights and it was nice to see it all in one place. … I will be recommending it to PhD students and Postdocs starting out on RSV research … . also recommend it to people who have been working with RSV for a while to dip in and out of to fill any gaps in the general knowledge.” (John Tregoning, Immunology News, May, 2014)

From the reviews: I enjoyed the book: as an immunologist who has spent 10 years working on RSV there were a number of novel insights and it was nice to see it all in one place. ... I will be recommending it to PhD students and Postdocs starting out on RSV research ... . also recommend it to people who have been working with RSV for a while to dip in and out of to fill any gaps in the general knowledge. (John Tregoning, Immunology News, May, 2014)

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