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OverviewUp until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood–brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS. Full Product DetailsAuthor: Thomas E. Lane , Monica Carson , Conni Bergmann , Tony Wyss-CorayPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of hardcover 1st ed. 2008 Dimensions: Width: 15.50cm , Height: 1.70cm , Length: 23.50cm Weight: 0.510kg ISBN: 9781441944801ISBN 10: 144194480 Pages: 318 Publication Date: 19 November 2010 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviewsFrom the reviews: The involvement of the immune system in central nervous system diseases is highlighted in this book, which details important advances in the understanding of certain aspects of neuroinflammation. ! This is clearly appropriate for clinicians and researchers who are interested in neuroinflammation in the central nervous system. It also can be a valuable research guide for students who are interested in learning some basics on this topic. ! It makes worthwhile contributions to this area. (Christine Maria Rohowsky-Kochan, Doody's Review Service, September, 2008) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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