Overview

This book provides leading edge research on a cell cycle, which is an ordered and highly controlled set of events that leads to cell growth and proliferation. Cell cycle progression is driven by changes in the substrate specificity and subcellular localisation of cyclin-dependent kinases (Cdks), which in turn are modulated by a collection of cyclins, Cdk-activating and Cdk-inhibiting kinases, and Cdk inhibitors (CDKIs). Regulation of the cell cycle is critical for the normal development of multicellular organisms and dysregulation of cell cycle could lead to cancer, a disease where normal cell growth and behaviour are lost. Cell cycle regulation is tightly controlled by both synthesis and degradation of short-lived proteins, such as cyclins and CDKIs, and degradation of these proteins is mainly mediated by the ubiquitin-dependent proteasome pathway.

Full Product Details

Author:   Nathan H Leroy ,  Noah T Fournier
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Dimensions:   Width: 26.00cm , Height: 3.60cm , Length: 18.00cm
Weight:   1.260kg
ISBN:  

9781604567960

ISBN 10:   1604567961
Pages:   496
Publication Date:   01 October 2008
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Preface; Insulin-Like Growth Factor Regulation of Cell Proliferation; The Beginning of the MicroRNA Era for Cell Cycle Control; TGFss: A Unique and Powerful Negative Regulator of the Cell Cycle in Human Myeloid Leukaemia Cells; Transforming Growth Factor Beta and Cell Cycle Regulation; Transcription Factor C/EBPa and its Effects on Cell Cycle Regulation; The Non-Hemodynamic Effect of Angiotensin II in Renal Fibrogenesis; Cyclin-Dependent Kinase Inhibitors and Aging; The Role and Predictive Power of Cell Cycle Checkpoints in Aging, Cardiovascular, Cancer, and Neurodegenerative Diseases; The Role of Cell Cycle Control Genes in the Pathogenesis of Human Hematological Neoplasms; Cell Cycle Control in Drosophila; Cell Cycle Control of Mammals during the Embryonic Period and Recent Research; An Innovative Educational Module for Community Pharmacists; Cell Cycle Arrest by Dietary Chemopreventive Agents; Chromatin: The Biophysical Approach to Elucidating Structure and Function; Index.

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