Overview

Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.

Full Product Details

Author:   Jukka Jolkkonen ,  Piotr Walczak
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   2013 ed.
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   3.285kg
ISBN:  

9783709116968

ISBN 10:   3709116961
Pages:   204
Publication Date:   26 June 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preclinical Optimization of Cell Therapies: Cell Therapy and Structural Plasticity Following Cerebral Ischemia.- Delivery Routes for Cell Therapy in Stroke.- Different Sources of Stem Cells for Transplantation Therapy in Stroke.- Efficacy of Transplant and Endogenous Precursor and Stem Cell Interventions on Stroke Recovery.- Translational Imaging Techniques to Study Cell Therapy: Cell Labeling Methods for Non-Invasive MR Imaging of Stem Cells.- Strategies for Enhanced, MRI-guided Targeting of Stem Cells to Stroke Lesions.- Image-guided Injection and Non-invasive Monitoring of Tissue Regeneration in the Stroke-damaged Brain.- Tracking of Autologous VSOP-Labelled Mesenchymal Stem Cells in the Sheep Brain Using 3T MRI.- Neural Stem Cell Mapping With High Resolution Rapid Scanning X-ray Fluorescence Imaging.- In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging.- Early Phase Clinical Studies: Clinical Trials.- Intravenous Cell Therapies for Stroke.- Intra-arterial Cell Therapy in Stroke Patients.- Intraventricular Route of Cell Transplantation for Stroke-Related Diseases.

Reviews

From the reviews: This book reviews the methodology of cell-based therapy and discusses potential applications. ... a valuable reference for researchers as well as clinicians who are interested in the evolving field of cell-based therapy. ... This book provides a balanced approach to cell-based therapy. ... The topics discussed here provide insight into the science of cell-based therapy. The information ... is for the most part presented in a manner readily understood by those who are not experts in the field. (Benjamin H. Eidelman, Doody's Book Reviews, August, 2013)

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