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OverviewCell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour.The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed.Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers. Full Product DetailsAuthor: Mary C Beckerle (Huntsman Cancer Institute and Department of Biology, University of Utah, USA)Publisher: Oxford University Press Imprint: Oxford University Press Volume: 39 Dimensions: Width: 18.80cm , Height: 2.40cm , Length: 24.50cm Weight: 0.949kg ISBN: 9780199638710ISBN 10: 0199638713 Pages: 426 Publication Date: 21 February 2002 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Out of Print Availability: Out of stock  Table of Contents1: Hansjurgen Volkmer: The immunoglobulin superfamily of cell adhesion molecules 2: Rodger P McEver: Selectins 3: Glenn L Radice and Masatoshi Takeichi: Cadherins 4: Bette Dzamba, Margaret Bolton and Douglas Desimone: The integrin family of cell adhesion molecules 5: Ofer Reizes, Pyong Woo Park, and Merton Bernfield: Cell surface heparan sulfate proteoglycans 6: Judith White, Dora Bigler, Michellee Chen, Yuji Takahashi, and Tyra Wofsberg: ADAMs 7: Susann Brady-Kalnay: Protein tyrosine phosphatases 8: Cara Gottardi, Carien Niessen, Barry Gumbiner: The adherens junction 9: Lynda Peterson and Keith Burridge: Focal adhesions and focal complexes 10: Leslie Bannon, Lawrence Goldfinger, Jonathan Jones, Kathleen Green: Desmosomes and hemidesmosomes 11: Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh: The tight junctionReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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