Overview

Cbl proteins are important ubiquitous regulators of various biological processes ranging from defense against infection to bone formation, and the list of these processes grows continuously. There are three Cbl-family proteins in mammals, which exhibit disparate biological effects. Furthermore, all metazoans appear to have Cbl-like proteins playing important regulatory roles in these organisms ranging from round worms and flies to amphibians and birds. One of the interesting peculiarities of the Cbl-mediated regulation is its dependence on multiple molecular mechanisms, which makes this regulation complex and difficult to comprehend. In spite of the considerable progress in the understanding of the Cbl family and its functions, which was achieved not without some unexpected and dramatic turns, Cbl proteins remain rather enigmatic. This book presents an in-depth analysis of the current state of knowledge on this subject. It discusses structure, functions and mechanisms of action of Cbl proteins, including biological and clinical implications of this knowledge. This important book can serve as a good primer for those who wish to enter the area of Cbl research, as well as a convenient reference for those already working in it.

Full Product Details

Author:   Alexander Tsygankov
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Dimensions:   Width: 26.00cm , Height: 2.00cm , Length: 18.00cm
Weight:   0.678kg
ISBN:  

9781604561685

ISBN 10:   1604561688
Pages:   210
Publication Date:   01 May 2008
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface; Welcome to the Family: Cbl-Family Gene Organisation, Overview Of Structure and Functions Of Cbl-Related Proteins in Various Taxonomical Groups; Cbl-Family Ubiquitin Ligases: Negative Regulators of Receptor Tyrosine Kinases; Cbl-family E3 Ubiquitin Ligases as regulators of non-receptor tyrosine Kinases; Cbl-Family Proteins as Molecular Adapters: Functions of Cbl Proteins Independent Of Ubiquitin Ligase Activity; Regulation of Immune Cell Signalling by c-Cbl and Cbl-b; The Roles of C-Cbl And Cbl-B In Bone: Multiple Functions of Cbl Proteins in a Complex Tissue; The Cbl Interactome; The Role of the E3 Ubiquitin Ligase Cbl-B in T-Cells Signalling and Tolerance; Cbl-C/Cbl-3: The Third Member of the Mammalian Cbl Family; Index.

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