Overview

The association between AIDS and cancer was recognized from the beginning of the AIDS epidemic, when the appearance of Kaposi sarcoma in a cluster of young men was one of the first signs of this new disease. It was soon recognized that AIDS was caused by infection with a novel virus (HIV) and that AIDS patients are prone to develop a number of “AIDS-defining” cancers: Kaposi sarcoma, lymphoma, and cervical cancer. The development of effective combination anti-HIV therapy starting around 1996 converted AIDS from a death sentence to a manageable disease and led to dramatic shifts in the epidemic. As this therapy was able to improve immune function in patients, the incidence of most “AIDS-defining” cancers decreased. There is a misconception, however, that AIDS has gone away. In fact, as AIDS patients are living longer, the number of AIDS patients has more than doubled in the United States since 1996, and the AIDS population overall has increased in age. Also, as AIDS patients are less likely to die of other complications, cancer is coming to the forefront as one of the most common causes of death in regions where AIDS drugs are widely available. Moreover, the three “AIDS-defining” cancers are now taking a back seat to a number of other HIV-associated cancers, such as Hodgkin lymphoma, lung cancer, and anal cancer. In the developing world, AIDS-associated cancers are a major public health problem, and in some regions of sub-Saharan Africa, Kaposi sarcoma is the most common tumor in men. In recent years, there has been a vast increase in our understanding of HIV-associated cancers. We now know, for example, that most are caused by other viruses and that the main role of HIV and immunodeficiency is to provide a supportive environment for the viruses to multiply and for the cancers to develop. But there remain a number of unanswered questions and a need for improved prevention and therapy. In the 28 chapters of this book, written by some of themost renowned experts in this field, we present up-to-date information on the cancers associated with HIV infection. The chapters cover the epidemiology of these cancers, their pathogenesis, their clinical presentation, and their treatment. The book will be of value to physicians, other medical professionals, students, and researchers with an interest in AIDS, viral-associated cancers, or HIV-associated malignancies. TABLE OF CONTENTS 1. HIV-associated Cancers: Overview Robert Yarchoan, Thomas Uldrick, Mark Polizotto 2. Epidemiology of AIDS-defining Malignancies William A. Blattner and Rebecca G. Nowak 3. Epidemiology of non-AIDS Defining Malignancies Andrew E. Grulich 4. HIV Cancers in Resource-Limited Regions Sam M. Mbulaiteye 5. Kaposi's Sarcoma-associated Herpesvirus (KSHV) Blossom Damania and Dirk P. Dittmer 6. Epstein Barr Virus (EBV) Lindsey Hutt-Fletcher 7. Human Papillomavirus (HPV) Zhi-Ming Zheng 8. Merkel Cell Polymavirus (MCV) Nicole Fischer and Adam Grundhoff 9. Presentation and Pathogenesis of Kaposi's Sarcoma Corey Casper 10. Management of Kaposi's Sarcoma Susan E. Krown 11. Presentation and Pathogenesis of HIV Lymphomas Richard F. Little, Stefania Pittaluga, Kieron Dunleavy 12. Diffuse Large B-Cell Lymphoma Neel K. Gupta and Lawrence D. Kaplan 13. Burkitt and Burkitt-Like Lymphoma Kishor Bhatia and Sam M. Mbulaiteye 14. Primary Effusion Lymphoma Giovanna Tosato 15. AIDS-related Central Nervous System Lymphoma Jan Davidson-Moncada and Thomas Uldrick 16. Plasmablastic and Other Lymphomas Huan-You Wang, Ida Wong-Sefidan, Erin Reid 17. Hodkin Lymphoma Michele Spina, Rosanna Ciancia, Accursio Augello 18. Multicentric Castelman Disease Mark N. Polizzotto, Thomas S. Uldrick, Robert Yarchoan 19. CervicalCancer Elizabeth A. Stier 20. Anal Cancer Joel Palefsky 21. Other HPV-Associated Cancers Kristina R. Dahlstrom and Erich M. Sturgis 22. Lung Cancer in HIV Infection Deepthi Mani and David M. Aboulafia 23. Hepattocellular Carcinoma in HIV-positive Patients Massimiliano Berretta, Paolo De Paoli, Umberto Tirelli, Bruno Cacopardo 24. Merkel Cell Carcinoma and Other HIV-associated Skin Cancers Nathalie C. Zeitouni adn Bethany Lema 25. Conjuctival Carcinoma Kenneth O. Simbiri and Erle S. Robertson 26. Malignancies in Children with HIV Infection D. Cristina Stefan 27. cART and Supportive Care Ronald T. Mitsuyasu 28. Stem Cell Transplantation Christine Durand and Richard Ambinder

Full Product Details

Author:   Robert Yarchoan
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2014 ed.
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   7.332kg
ISBN:  

9781493908585

ISBN 10:   1493908588
Pages:   389
Publication Date:   11 July 2014
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

HIV-associated Cancers: Overview.- Epidemiology of AIDS-defining Malignancies.- Epidemiology of non-AIDS Defining Malignancies.- HIV Cancers in Resource-limited Regions.- Kaposi's Sarcoma-associated Herpesvirus (KSHV).- Epstein Barr Virus (EBV).- Human Papillomavirus (HPV).- Merkel Cell Polymavirus (MCV).- Presentation and Pathogenesis of Kaposi's Sarcoma.- Management of Kaposi's Sarcoma.- Presentation and Pathogenesis of HIV Lymphomas.- Diffuse Large B-Cell Lymphoma.- Burkitt and Burkitt-Like Lymphoma.- Primary Effusion Lymphoma.- AIDS-related Central Nervous System Lymphoma.- Plasmablastic and Other Lymphomas.- Hodkin Lymphoma.- Multicentric Castelman Disease.- Cervical Cancer.- Anal Cancer.- Other HPV-Associated Cancers.- Lung Cancer in HIV Infection.- Hepattocellular Carcinoma in HIV-positive Patients.- Merkel Cell Carcinoma and Other HIV-associated Skin Cancers.- Conjuctival Carcinoma.- Malignancies in Children with HIV Infection.- cART and Supportive Care.- Stem Cell Transplantation.

Reviews

From the book reviews: This book aims to provide a comprehensive understanding of the various mechanisms of oncogenesis in HIV patients and to focus upon the prevention, diagnosis, and management of a broad array of HIV-related malignancies. ... The audience includes students, residents, practitioners, and professors in the medical community. This is an appropriate audience. The authors are experts in their respective fields and do an excellent job of conveying complex information in an accessible manner. (Joseph C. Alvarnas, Doody's Book Reviews, October, 2014)

From the book reviews: This book aims to provide a comprehensive understanding of the various mechanisms of oncogenesis in HIV patients and to focus upon the prevention, diagnosis, and management of a broad array of HIV-related malignancies. The audience includes students, residents, practitioners, and professors in the medical community. This is an appropriate audience. The authors are experts in their respective fields and do an excellent job of conveying complex information in an accessible manner. (Joseph C. Alvarnas, Doody s Book Reviews, October, 2014)

From the book reviews: “This book aims to provide a comprehensive understanding of the various mechanisms of oncogenesis in HIV patients and to focus upon the prevention, diagnosis, and management of a broad array of HIV-related malignancies. … The audience includes students, residents, practitioners, and professors in the medical community. This is an appropriate audience. The authors are experts in their respective fields and do an excellent job of conveying complex information in an accessible manner.” (Joseph C. Alvarnas, Doody’s Book Reviews, October, 2014)

Author Information

Dr. Robert Yarchoan is the Director of the Office of HIV and AIDS Malignancy and Chief of the HIV and AIDS Malignancy Branch in the National Cancer Institute. He played a major role in developing the first AIDS drugs. His research is now focused on AIDS-related cancers, especially Kaposi sarcoma and other cancers caused by Kaposi sarcoma-associated herpesvirus.

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