Overview

This book is about calreticulin, a multifunctional calcium binding protein first discovered over 20 years ago. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. This volume outlines the newly discovered functions for calreticulin including its control of calcium homeostasis, modulation of steroid-sensitive gene expression, control of viral RNA replication, modulation of nuclear transport, role in T lymphocyte activation and cytotoxic killing, chaperone function, control of adhesion-dependent signaling via integrins, possible role in the biology of ticks, in the pathology of autoimmune diseases and in blood function.

Full Product Details

Author:   Marek Michalak
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1996
Dimensions:   Width: 17.80cm , Height: 1.20cm , Length: 25.40cm
Weight:   0.448kg
ISBN:  

9783662062050

ISBN 10:   3662062054
Pages:   217
Publication Date:   03 October 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. A Current History of Calreticulin.- 2. Basic Characteristics and Ion Binding to Calreticulin.- 3. The Intracellular Distribution and Expression of Calreticulin.- 4. The Roles of Calnexin and Calreticulin as Endoplasmic Reticulum Molecular Chaperones.- 5. Calreticulin and Ca2+ Storage.- 6. Calreticulin and the Modulation of Gene Expression.- 7. Role of Calreticulin in Rubella Virus Replication.- 8. Calreticulin and Autoimmunity.- 9. Calreticulin in T. Lymphocytes.- 10. Calreticulin and Thrombosis.- 11. Calreticulin in Vector Arthropods—The Secreted Calreticulin.- 12. Protein Nuclear Import Is Modulated by Calreticulin.

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