Free Delivery Over $100
|
|
|||
|
||||
OverviewThe central nervous system (CNS) represents the organ with the highest struc- tural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one ofthe major chal- lenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfinding) have been addressedinDrosophilaby focusing on the relatively simply structuredtruncal partsofthe nervous system. However, informationprocess- ing (e. g. , vision, olfaction), behavior, learning and memory require highly special- ized structures, which are located in the brain. Owing to much higher complexity and hidden segmental organisation, our understandingofbrain development is still quite rudimentary. Considerable advances have been made recently in bringing the resolution ofbrain structures to the level ofindividual cells and their lineages, which significantly facilitates investigations into the mechanisms controlling brain development. This book provides an overview of some major facets of recent research on Drosophila brain development. The individual chapters were written by experts in each field. V. Hartenstein et al survey the generic cell types that make up the developing brain and describe themorphogenesisofneural lineages and theirrelation- ship to neuropil compartments in the larval brain. Recent findings on anteroposterior regionalization and on dorsoventral patterning in the embryonic brain are reviewed in the chapters by R. Lichtneckert and H. Reichert and by R. Urbach and G. Technau, respectively. Both processes show striking parallels betweenDrosophila and mouse. Full Product DetailsAuthor: Gerhard Martin TechnauPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2008 ed. Volume: 628 Dimensions: Width: 17.80cm , Height: 1.50cm , Length: 25.40cm Weight: 0.580kg ISBN: 9780387782607ISBN 10: 0387782605 Pages: 160 Publication Date: 28 March 2008 Audience: College/higher education , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsCONTENTS 1. The Development of the Drosophila Larval Brain........... 1 Volker Hartenstein, Shana Spindler, Wayne Pereanu and Siaumin Fung Abstract................................................................................................................................. 1 Synopsis of the Phases and Elements of Drosophila Brain Development........................ 1 Progenitors of the Drosophila Brain: Neuroblasts and Ganglion Mother Cells............. 3 The Generic Cell Types of the Drosophila Brain................................................................ 8 Neuroanatomy of the Developing Drosophila Brain: The Systems of Lineages, Tracts and Compartments......................................................................................... 17 Outlook............................................................................................................................... 29 2. Anteroposterior Regionalization of the Brain: Genetic and Comparative Aspects............................................. 32 Robert Lichtneckert and Heinrich Reichert Abstract............................................................................................................................... 32 Introduction........................................................................................................................ 32 The Cephalic Gap Genes Otd/Otx and Ems/Emx Control Anterior Brain Development..................................................................................................... 34 The Hox Genes Pattern the Posterior Brain..................................................................... 36 Evidence for a Tripartite Organization of the Brain....................................................... 37 3. Dorsoventral Paterning of the Brain: A Comparative Approach.................................................................. 42 Rolf Urbach and Gerhard M. Technau Abstract ............................................................................................................................... 42 Introduction........................................................................................................................ 42 DV Patterning of the Truncal Part of the CNS in Drosophila and vertebrates............ 45 DV patterning of the brain in Drosophila........................................................................ 48 A comparison with DV regionalization of the vertebrate telencephalon................... 52 Conclusions......................................................................................................................... 53 xii Contents 4. Disection of the Embryonic Brain Using Photoactivated Gene Expresion.............................................. 57 Jonathan Minden Abstract............................................................................................................................... 57 Introduction........................................................................................................................ 57 Procephalic Blastoderm Fate Map.................................................................................... 58 Brain-Forming Mitotic Domains Populate Distinct Brain Regions............................... 58 Conclusion.......................................................................................................................... 67 5. Design of the Larval Chemosensory System....................... 69 Reinhard F. Stocker Abstract ............................................................................................................................... 69 Introduction........................................................................................................................ 69 Chemosensory Organs of the Larval Head...................................................................... 70 Olfactory System................................................................................................................. 71 Gustatory System................................................................................................................ 77 The Drosophila Larva as a Model for Smell and Taste.................................................... 78 6. Development of the Drosophila Olfactory System...... 82 Veronica Rodrigues and Thomas Hummel Abstract............................................................................................................................... 82 Introduction........................................................................................................................ 82 Organization of the Drosophila Adult Olfactory System................................................. 84 Specification of the Olfactory Sense Organs.................................................................... 84 Olfactory Lineages Revisited............................................................................................. 87 Origin of Glial Cells............................................................................................................ 89 Development of ORN Connectivity................................................................................... 89 Olfactory Map Organization............................................................................................. 90 Cellular and Molecular Mechanisms of ORN Wiring Specificity.................................. 91 Specification of Projection Neurons.................................................................................. 92 Development of PN Dendrites............................................................................................ 95 Concluding Remarks.......................................................................................................... 96 7. The Olfactory Sensory Map in Drosophila.......................... 102 Philippe P. Laissue and Leslie B. Vosshall Abstract............................................................................................................................. 102 Introduction...................................................................................................................... 102 Olfactory Organs and Olfactory Sensory Neurons of Drosophila................................ 103 Odorant Receptor Gene Expression................................................................................ 104 Ligand Tuning Profiles..................................................................................................... 105 A Receptor-Based Map of Glomerular Projections....................................................... 108 Sexual Dimorphism in the Drosophila Olfactory System...............................................111 Concluding Remarks........................................................................................................ 112 8. Optic Lobe Development.................................................................115 Karl-Friedrich Fischbach and Peter Robin Hiesinger Abstract............................................................................................................................. 115 Introduction...................................................................................................................... 115 The Adult Visual System Is Organized into Parallel Visuotoptic Functional Pathways................................................................................................. 116 Lamina Development........................................................................................................ 120 Medulla and Lobula Complex Development.................................................................. 126 Concluding Remarks........................................................................................................ 131 9. Clonal Unit Architecture of the Adult Fly Brain........ 137 Kei Ito and Takeshi Awasaki Abstract............................................................................................................................. 137 Introduction...................................................................................................................... 137 Structure of the Adult Brain............................................................................................ 137 Techniques for Visualising Clonally Related Progeny................................................... 139 Clonal Unit Architecture in the Adult Brain.................................................................. 147 Formation of the Clonal Units During Development..................................................... 150 Functional Importance of the Clonal Units.................................................................... 154 Conclusion........................................................................................................................ 156 INDEX.............................................................................................................................TBAReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
||||
