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OverviewFull Product DetailsAuthor: Leonardo LeonardiPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2022 Weight: 0.332kg ISBN: 9783030902124ISBN 10: 3030902129 Pages: 193 Publication Date: 22 December 2022 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsContents Preface CHAPTER 1: OUTLINE OF ANATOMY/PHYSIOLOGY OF SKELETAL TISSUES 1. Structure and Physiology of Skeletal Tissue 1.1 Bone tissue 1.2 Bone cells 1.3 Bone tissue organization 1.4 Normal bone development 1.5 Types of skeletal tissues 1.6 Bone and cartilage as skeletal tissues 1.7 Functions of bone in the skeleton 1.8 Origin and dynamic functions of the skeleton and their origins 1.9 Ultrastructure of cells of the skeleton 1.10 Cells of skeleton derived from neural crest 1.11 Fibroblasts, fibrocytes and myofibroblasts in the skeleton 1.12 Monocytes, macrophages and histiocytes 1.13 Chondroblasts and chondrocytes 1.14 Osteoblasts, osteocytes and osteoclasts 1.15 Smooth muscle cells 1.16 Striated skeletal muscle cells 1.17 Lipoblasts and lypocytes 1.18 Angioblasts, vascular endothelium, pericites 1.19 Synovium 1.20 Mast Cells 1.21 Cells of neural crest origin CHAPTER 2: TUMORS OF THE MUSCULOSKELETAL SYSTEM 2.1 Terminology 2.2 Abnormal growths discussed vs skeletal tumors 2.3 Benign vs malignant bone tumors 2.4 Cellular features: metaplasia and anaplasia 2.5 Tumor progression: last phase in tumor development 2.6 Predisposing conditions and genetic predisposition 2.7 Tumor site of origin defines tumor categories for osteosarcoma: 2.7.1 Periosteal origin: Periosteal, Parosteal and Surface osteosarcomas 2.7.2 Medullary origin: Intramedullary (syn, Intracortical) 2.8 Introduction to tumors of bone 2.9 WHO classification scheme for domestic animal bone tumors 2.10 Tumors of bone in animals: categories, frequency and clinical behavior 2.11 Benign tumors of bone 2.11.a. Osteoma: Clinical, radiographic, CT, MRI, and microscopic features 2.11.b. Osteoblastoma: Uncommon but features are described 2.11.c. Myxoma of jaw: Uncommon; clinical and histologic features are described 2.11.d. Osteochondroma: Growth plate dysplasia; structural features are described 2.11.e. Feline osteochondromatosis: C-retroviral periosteal progressive growth 2.11.f. Chondroma of bone: Periosteal nodule with clinical & structural features 2.11.g. Hemangioma of bone: Medullary vascular lesion with features described 2.11.h. Table comparing features of selected benign and malignant tumors 2.12 Malignant tumors of bone 2.12.a. Historical discussion: Spectrum of premalignant lesions, invasive but non metastatic tumors, low-grade to highly malignant bone tumors 2.12.b. Barriers to tumor expansion; tumor locations in a bone 2.12.c. Osteosarcoma: Definition and pathogenesis 2.12.c.1. Central (syn. medullary, conventional and classic osteosarcoma): Ultrastructure, staging, grading, genetic biomolecular information. Diagnostic features described for each example Poorly differentiated Osteoblastic: nonproductive and productive Chondroblastic Fibroblastic Telangiectatic Giant cell type 2.12.c.2 Periosteal origin: Periosteal, Parosteal and Surface osteosarcomas Etiology, radiographic, gross and histopathologic features described Parosteal osteosarcoma is tumor arising on a bone surface, i.e., a juxtacortical osteosarcoma 2.12.d. Chondrosarcoma: Clinical, radiographic, gross, microscopic and immunohistochemical staining features and a differential diagnosis are presented Table compares: Low, intermediate and high-grade features Flow diagram of malignant change from MSC to chondrosarcoma 2.12.e. Fibrosarcoma: Clinical, gross, radiographic, microscopic findings and differential diagnosis are presented. List of 8 key diagnostic microscopic features for malignancy 2.12.f. Hemangiosarcoma: Clinical, gross, radiographic, microscopic findings and differential diagnosis are presented 2.12.g. Giant cell tumor of bone: Clinical, gross, radiographic, microscopic findings and differential diagnosis are presented List of 8 key diagnostic microscopic features for malignancy 2.12.h. Multilobular tumor of bone 2.12.i. Synovial sarcoma 2.12.j. Liposarcoma 2.12.k. Malignant mesenchymoma 2.13 OTHERS UNCOMMON BONE TUMORS 2.13.1 Myxosarcoma 2.14 Tumors of bone marrow 2.14.1 Myeloma and multiple myeloma 2.14.2 Lymphoma 3. TUMOR-LIKE LESIONS OF THE MUSCULOSKELETAL SYSTEM 3.1 Fibrous dysplasia 3.2 Solitary bone cyst: Clinical, gross, microscopic findings and differential diagnosis are presented 3.3 Juxtacortical bone cyst: Lesions in animals are compared to those in man. 3.4 Epidermoid cyst of the phalanx: clinical, gross, microscopic findings and differential diagnosis are presented 3.5 Myositis ossificans: This is a benign lesion that arises in the fascial planes of muscle likely from mesenchymal stem cells provoked by trauma. It has characteristic tri-layer histologic features. Clinical, gross and histopathologic features are presented. 3.6 Villonodular synovitis of joints 4. GENERAL CONSIDERATIONS ABOUT BONE TUMORS: 4.1 Primitive tumor index: T-index 4.2 Distant metastasis: M-index 4.3 Histologic grade: G-index 4.4 Staging index: I-III with substages and Table for man (Enneking, 1983) 4.5 Specimen selection, processing and histologic methods for evaluating bone specimens CHAPTER 5: Appendix: Manual for histological preparation and examination of tissues containing bone and cartilage: 5.1 Importance of history, clinical findings, imaging interpretation from clinical radiographs, angiography, nuclear bone scan, CT, MRI, ultrasound, needle aspiration and cytology, trochar biopsy, excisional biopsy, fixation, decalcification, embedment, sectioning, selection of histologic stains and immunohistochemical stains 5.2 Histologic examination while considering prior clinical and imaging information in making a diagnosis. 6. References:1-630 7. AcknowledgementsReviewsAuthor InformationDr. Leonardi's research is mainly focused on the study of spontaneous bone tumors and skeletal diseases in domestic animals. After years of morphological and immunohistochemical investigations in different types of primary bone tumors such as osteosarcoma and giant cell tumor of bone, the Dr. Leonardi is currently working on the biomolecular and comparative genetic characterization of animal and human spontaneous osteosarcomas. Tab Content 6Author Website:Countries AvailableAll regions |
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