Overview

This book describes biosynthetic methods to synthesize heterocycliccompounds, offering a guide for the development of new drugs basedon natural products. The authors explain the role of naturalproducts in chemistry and their formation along with importantanalytical methods and techniques for working withheterocycles.- Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification- Provides a thorough resource of informationspecifically on heterocyclic natural products and their practicalbiosynthetic relevance- Explains the role of natural products in chemistry andtheir formation- Discusses gene cluster identification and the use ofbiogenetic engineering in pharmaceutical application

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9781322877211

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Patrizia Diana is full Professor of Medicinal Chemistry at the University of Palermo. She is currently coordinator of the Medicinal and Biological Section of the Department of Science and Technology: Chemical, Biological, and Pharmaceutical (STEBICEF); and is a member of the Italian Chemical Society and International Society of Heterocyclic Chemistry.Girolamo Cirrincione is full Professor of Medicinal Chemistry at the University of Palermo. He is a member of the Drug Discovery Committee of the Pharmacology and Molecular Mechanisms (PAMM)Group of the European Organization for Research and Treatment of Cancer; the Italian Chemical Society, where he is currently serving as President of the Medicinal Chemistry Division; and the International Society of Heterocyclic Chemistry, where he served as vice president for 2004-05

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