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Overview"""an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus…. the ample problems and tutorials throughout are much appreciated."" –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago ""Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels."" –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University ""a masterful tour de force…. Barrick's rigor and scholarship come through in every chapter."" –Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon." Full Product DetailsAuthor: Douglas Barrick (Johns Hopkins University, Baltimore, Maryland, USA)Publisher: Taylor & Francis Ltd Imprint: CRC Press Weight: 1.905kg ISBN: 9781138068841ISBN 10: 1138068845 Pages: 552 Publication Date: 08 September 2017 Audience: College/higher education , Professional and scholarly , Tertiary & Higher Education , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsSeries Preface Preface Acknowledgments Note to Instructors Author Chapter 1 Probabilities and Statistics in Chemical and Biothermodynamics Chapter 2 Mathematical Tools in Thermodynamics Chapter 3 The Framework of Thermodynamics and the First Law Chapter 4 The Second Law and Entropy Chapter 5 Free Energy as a Potential for the Laboratory and for Biology Chapter 6 Using Chemical Potentials to Describe Phase Transitions Chapter 7 The Concentration Dependence of Chemical Potential, Mixing, and Reactions Chapter 8 Conformational Equilibrium Chapter 9 Statistical Thermodynamics and the Ensemble Method Chapter 10 Ensembles That Interact with Their Surroundings Chapter 11 Partition Functions for Single Molecules and Chemical Reactions Chapter 12 The Helix–Coil Transition Chapter 13 Ligand Binding Equilibria from a Macroscopic Perspective Chapter 14 Ligand Binding Equilibria from a Microscopic Perspective Appendix: How to Use Mathematica 485 Bibliography IndexReviewsPresents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels. -Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University a masterful tour de force.... Barrick's rigor and scholarship come through in every chapter. The focus on biomolecules combined with the detailed demonstrations of how concepts apply to practical aspects of biophysics make this a truly unique contribution. Everyone, from the purported expert to the true novice will gain immensely from this carefully crafted, well motivated, and deeply thought out contribution. This book should live on all of our bookshelves and be consulted routinely as a quick reference or as material for in depth study and training. ã -Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis The author has created an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus. It starts by bringing students up to speed on probability theory, multi-variate calculus and data fitting, the necessary tools for tackling the advanced topics covered in the remaining dozen chapters and for conducting rigorous interdisciplinary research.... the ample problems and tutorials throughout are much appreciated. -Tobin R. Sosnick, Professor and Chair, Dept of Biochemistry and Molecular Biology, University of Chicago Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels. -Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University a masterful tour de force.... Barrick's rigor and scholarship come through in every chapter. The focus on biomolecules combined with the detailed demonstrations of how concepts apply to practical aspects of biophysics make this a truly unique contribution. Everyone, from the purported expert to the true novice will gain immensely from this carefully crafted, well motivated, and deeply thought out contribution. This book should live on all of our bookshelves and be consulted routinely as a quick reference or as material for in depth study and training. ã -Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis The author has created an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus. It starts by bringing students up to speed on probability theory, multi-variate calculus and data fitting, the necessary tools for tackling the advanced topics covered in the remaining dozen chapters and for conducting rigorous interdisciplinary research.... the ample problems and tutorials throughout are much appreciated. -Tobin R. Sosnick, Professor and Chair, Dept of Biochemistry and Molecular Biology, University of Chicago Author InformationDouglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned a Ph.D. in biochemistry from Stanford University (1993) and Ph.D. in biophysics and structural biology from the University of Oregon (1996). He has been honored as recipient of the Beckman Young Investigator award, the Helen Hay Whitney Postdoctoral fellowship, and Howard Hughes Medical Institute Predoctoral Fellowship. He has been an editorial board member of the journals Protein Science and Biophysical Journal, and has been an organizer of the Gibbs Conference on Biothermodynamics. Research in his lab focuses on the study of protein evolution, folding, and assembly. Tab Content 6Author Website:Countries AvailableAll regions |
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