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Author:   Rodrigo Machado-Vieira (Experimental Therapeutics and Molecular Pathophysiology Program, UTHealth Harris County Psychiatric Center (HCPC)) ,  Jair Soares (University of Texas Health Medical School, Houston, TX, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780128213988

ISBN 10:   0128213981
Pages:   400
Publication Date:   01 December 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Biomarkers in Bipolar Disorder: Overview 2. RNA and Micro-RNA Biomarkers in Bipolar Disorder 3. Metabolomics in Bipolar Disorder 4. Behavioral Models of Bipolar Disorder 5. Structural Neuroimaging in Bipolar Disorder 6. Neurochemical Imaging Findings in Bipolar Disorder 7. Pharmacogenomics and Precision Psychiatry in Bipolar Disorder 8. Translating Biomarkers from Bench to Bedside in Bipolar Disorder 9. Genetic (GWAS) Biomarkers in Bipolar Disorders 10. Mitochondrial Dysfunction in Bipolar Disorder 11. Aging Mechanisms in Bipolar Disorder 12. Staging and Neuroprogression in Bipolar Disorders 13. Neuro-immune Pathways in Bipolar Disorder 14. Glutamatergic Dysfunction in Bipolar Disorder 15. Neurocognitive Endophenotypes and Biomarkers in Bipolar Disorder 16. DNA Methylation in Bipolar Disorder 17. Biomarkers of Lithium Efficacy in Bipolar Disorders 18. Neuroendocrine Pathways in Bipolar Disorders 19. Intracellular Signaling in Bipolar Disorder 20. Circadian Rhythms and Bipolar Disorder 21. DNA Damage and Repair Mechanisms in Bipolar Disorder 22. Microbiome and Bipolar Disorder 23. Bipolar Disorder and Plasticity: A Key Target for New Treatments 24. Proteomic Approaches for Biomarker Discovery in Bipolar Disorder 25. Drug Development in Bipolar Disorders: New Therapeutic Targets

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Author Information

Rodrigo Machado-Vieira, MD, PhD, MSc, is a professor of psychiatry and behavioral sciences and director of the Experimental Therapeutics and Molecular Pathophysiology Program at UTHealth Harris County Psychiatric Center (HCPC). He was previously at the National Institue of Mental Health (NIMH) from 2012-2016, as the director of the Translational Research Clinic in Mood Disorders at the Experimental Therapeutics and Pathophysiology Branch. Machado-Vieira received his MD from PUC-RS in Porto Alegre, Brazil and his PhD in Psychiatry at the University of Sao Paulo, following his residency training in Psychiatry at the Federal University of Health Sciences. After a postdoctoral fellowship at the Laboratory of Molecular Pathophysiology and Experimental Therapeutics at NIMH, he was the chief of the Mood Disorders Program, LIM-27 and professor of Psychiatry at the Institute of Psychiatry, University of Sao Paulo, Brazil. He has received several grants and awards for his research on mood disorders including the National Institutes of Health Fellows Award for Research Excellence, the Brazilian Psychiatric Association Award, the Gerald Klerman Young Investigator Award, Depression and Bipolar Support Alliance (DBSA), Sao Paulo Young Investigator Research Award, and the Stanley Medical Research Institute Research Award. Has more than 200 articles published and more than 6,400 citation of his articles. Jair C. Soares, MD, PhD, joined UTHealth in 2009 and currently serves as professor and Pat R. Rutherford, Jr. Chair in Psychiatry at McGovern Medical School and as executive director of UTHealth Harris County Psychiatric Center. A Board-certified psychiatrist, he also serves as chief of Psychiatry Services at Memorial Hermann Hospital and LBJ Hospital. The sites provide patient care and serve as clinical training facilities for UTHealth medical students, psychiatry residents and psychiatry fellows. Soares directs the Center of Excellence on Mood Disorders which focuses on the search for the causes and the development of new treatments for mood disorders. The center is comprised of an active research team who specializes in clinical neurosciences (neuroimaging, neurophysiology, cognitive neurosciences, and genetics), as well as clinical psychopharmacology and interventions research. After receiving his medical degree from the University of Sao Paulo in Brazil in 1990, Soares accepted a psychiatric residency in adult psychiatry at the University of Sao Paulo and a research tract residency in general psychiatry at the Western Psychiatric Institute and Clinic at the University of Pittsburgh. Subsequently, Soares received a brain imaging fellowship with the Yale University School of Medicine Department of Psychiatry. He obtained a PhD in medical sciences at the Federal University of Rio Grande do Sul in Brazil. Prior to joining UTHealth, Soares served as the Distinguished Professor of Psychiatry and Director of the Center of Excellence in Research and Treatment for Bipolar Disorders at the University of North Carolina at Chapel Hill and as Deputy Chair for Research and Division Chief for Mood and Anxiety Disorders with the Department of Psychiatry at The University of Texas Health Science Center at San Antonio. Soares has received numerous honors and awards, including the National Plaque of Honor, Republic of Panama, the Devereux Clinic Emy Award, and the Best Doctor Award. He published more than 200 peer-reviewed articles and book chapters in the psychiatric literature and has held editorial positions on a number of national and international medical journals. Since April 2015, he is also the co-editor in chief for the Journal of Affective Disorders.

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