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OverviewPhosphoinostides have been known to play a role in cell signalling since the 1950s and since then, lipid signals have been discovered to play a role in many different cellular functions. Biology of Phosphoinostides is not a historical account, but a review of the current opinions of lipid signalling research with the emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate but now anyone ignoring one area at the expense of the other does so at their peril. The regulation of phospholipase C (and its isozymes), phospholipase D, the phosphinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth. There is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation- state of membrane proteins. The central issue of the control of synthesis, translocation, and degradation of phosphoinositides is also given due coverage. For too long, lipids have been seen as a backwater of biology and an uninteresting topic to study. However their central role in cell function is now properly recognized and the Biology of Phosphoinositides will serve as an enjoyable and intriguing introduction to what these slippery molecules can achieve. Full Product DetailsAuthor: Shamshad Cockcroft (Department of Physiology, University College London)Publisher: Oxford University Press Imprint: Oxford University Press Volume: 27 Dimensions: Width: 18.80cm , Height: 2.20cm , Length: 24.60cm Weight: 0.804kg ISBN: 9780199637645ISBN 10: 0199637644 Pages: 366 Publication Date: 20 April 2000 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Out of Print Availability: Out of stock  Table of ContentsRegulation of Phosphoinositide-specific Phospholipase C isozymes Phosphoinositide- 3-kinases - Regulation by cell surface receptors and function of 3-phosphorylated lipids Enzymes involved in the synthesis of phosphatidylinositol 4,5 bisphosphate and their regulation - Phosphoinositide kinases Pleckstrin Homology Domains: Phosphoinositide-regulated membrane tethers Regulation of cytoskeletal protein by inositol lipids Physiological functions phosphatidylinositol transfer proteins Glycosyl-phosphatidylinositol anchored proteins and their phospholipases Phosphatidylinositol 3 kinase and membrane traffic Regulation of Phospholipase D signalling by phosphoinositides Regulation of chloride channel conductance by inositol (3,4,5,6) tetraphosphate; A phosphoinositide-initiated signalling pathway that acts downstream of inositol (1,4,5) trisphosphate Phosphatases for inositol lipids and for inositol phosphatesReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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