Overview

Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.

Full Product Details

Author:   M. García-Sancho
Publisher:   Palgrave Macmillan
Imprint:   Palgrave Macmillan
Dimensions:   Width: 14.00cm , Height: 1.50cm , Length: 21.60cm
Weight:   0.455kg
ISBN:  

9780230250321

ISBN 10:   0230250327
Pages:   242
Publication Date:   11 May 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction: An Historical Approach to Sequencing PART I: EMERGENCE: FREDERICK SANGER'S PIONEERING TECHNIQUES (1943-1977) The Sequence of Insulin and the Configuration of a New Biochemical Form of Work (1943-1962) From Chemical Degradation to Biological Replication (1962-1977) PART II: MECHANISATION – 1: COMPUTING AND THE AUTOMATION OF SEQUENCE RECONSTRUCTION (1962-1987) Sequencing Software and the Shift in the Practice of Computation Sequence Databases and the Emergence of 'Information Engineers' PART III: MECHANISATION – 2: THE SEQUENCER AND THE AUTOMATION OF SEQUENCE CONSTRUCTION (1980-2000) A New Approach to Sequencing at Caltech The Commercialisation of the DNA Sequencer Conclusions: A Long History of Practices Appendix 1: Oral Histories Appendix 2: Archival Sources Notes Bibliography

Reviews

'Overall, this book provides a detailed time line of the events from the earliest methodologies to the metagenomic sequencing standard of today, and is a useful resource for anyone interested in the historical angle of DNA sequencing. Highy recommended.' - M.C. Pavao, Worcester State College, Choice

Author Information

Miguel Garcia-Sancho obtained his Ph.D. at Imperial College London, UK, and has worked at the University of Manchester and Spanish National Research Council (CSIC). He is currently a Chancellor's Fellow at the Department of Science, Technology and Innovation Studies of the University of Edinburgh. His interests lay in the history and social studies of twentieth century biomedicine, as well as science communication and free-lance scientific journalism.

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