Overview

Depression is not simply a matter of emotion-it is a deeply biological and neuropsychological condition that reshapes the brain, the body, and the mind. Biology and Neuropsychology of Depression offers a comprehensive, accessible, and scientifically grounded journey into the hidden mechanisms that drive one of the world's most widespread mental health challenges. Drawing on cutting-edge research in neuroscience, endocrinology, genetics, and cognitive psychology, the book reveals how neural circuits malfunction, how stress alters hormonal systems, and how inflammation, neurotransmitters, and epigenetic changes contribute to depressive states. Rather than reducing depression to a single cause, Adrian Blake presents it as a dynamic interplay of biology, experience, and cognition. Readers will discover how the limbic system, prefrontal cortex, and reward pathways shape mood; why memory, attention, and decision-making change during depressive episodes; and how lifelong vulnerability can arise from early-life stress or genetic predisposition. Yet this book is not only about mechanisms-it is also about hope. It explores how neuroplasticity enables recovery, how modern treatments restore disrupted brain networks, and how lifestyle, therapy, and emerging medical approaches can foster resilience. Written with clarity and depth, Biology and Neuropsychology of Depression is an essential guide for students, clinicians, researchers, and anyone seeking to understand depression through the lens of modern science.

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