Overview

Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are reviewed in this volume by authors from over sixty of the world's leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is essential reading for investigators of DNA replication, cell cycle control, and tumorigenesis.

Full Product Details

Publisher:   Cold Spring Harbor Laboratory Press,U.S.
Imprint:   Cold Spring Harbor Laboratory Press,U.S.
Volume:   v. 65
Dimensions:   Width: 18.00cm , Height: 4.70cm , Length: 20.60cm
Weight:   1.671kg
ISBN:  

9780879696061

ISBN 10:   0879696060
Pages:   613
Publication Date:   21 May 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Symposium Participants Foreword Mutation Response and Error Bypass (G.C. Walker, M. Radman, P.L. Foster, M.F. Goodman, E.C. Friedberg, L. Prakash, C.W. Lawrence, F. Hanaoka, T.A. Kunkel) Base Recognition and Excision Repair (E.T. Kool, G.L. Verdine, J.A. Tainer, T. Lindahl, E. Seeberg, S.H. Wilson, A. Sancar) Nucleotide Excision Repair (R.D. Wood, P.C. Hanawalt, G. Mer, P.K. Cooper) Mismatch Repair (R. Fishel, W. Yang, K. Morikawa, J.H. Miller) Telomeres and the Stability of DNA Ends (E.H. Blackburn, T. de Lange, C.W. Greider, D.E. Gottschling, L. Guarente, J.E. Haber, S.C. West) Damage Control during Replication and Mitosis (P. Nurse, J.F.X. Diffley, R. Rothstein, E.J. Foss, P. Russell, P.K. Sorger, C.L. Rieder) Genome Stability and Checkpoint Control (J.F. Ward, L.D. Samson, F.W. Alt, J.H.J. Petrini, S.J. Elledge, S.P. Jackson, R.D. Kolodner, T. Weinert, M. Yanagida, A.M. Carr, R.S. Weiss, M.O. Hengartner) p53 and the DNA Damage Response (A.J. Levine, D. Lane, C. Prives, S.W. Lowe, G. Wahl) DNA Damage and Cancer Progression (M.B. Kastan, Y. Shiloh, D.M. Livingston, J.H. Chung, M. Jasin, S.A. Leadon, A.R. Venkitaraman, I.D. Hickson, Z.-Q. Wang) Summary (E.C. Friedberg)

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