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OverviewFull Product DetailsAuthor: Patrick M. Dansette , Robert R. Snyder , Terrence J. Monks , David J. JollowPublisher: Springer Science+Business Media Imprint: Kluwer Academic/Plenum Publishers Edition: 2001 ed. Volume: 500 Dimensions: Width: 17.80cm , Height: 5.50cm , Length: 25.40cm Weight: 1.617kg ISBN: 9780306466595ISBN 10: 0306466597 Pages: 728 Publication Date: 30 November 2001 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsKeynote Presentation; S. Orrenius, et al. Session I. Structure Activity Relationships for the Chemical Behaviour and Toxicity of Electrophilic Quinones/Quinone Methides; I.M.C.M. Rietjens, et al. Use of Structure-Activity Relationships for Probing Biochemical Mechanisms: Glutathione Transferase Zeta Conjugation of Haloacids; P.D. Swartz, A.M. Richard. Structure Toxicity Relationships - How Useful are They in Predicting Toxicities of New Drugs? S.D. Nelson. Session II. Biological Reactive Intermediates in Drug Discovery and Development A Perspective from the Pharmaceutical Industry; T.A. Baillie, K. Kassahun. Bioactiviation of Toxicants by Cytochrome P450-Mediated Dehydrogenation Mechanisms; G.S. Yost. New Aspects of DNA Adduct Formation by the Carcinogens Crotonaldehyde and Acetaldehyde; S.S. Hecht, et al. Mechanisms of Ovotoxicity Induced by Environmental Chemicals: 4-Vinylcyclohexene Diepoxide as a Model Chemical; P.B. Hoyer, et al. Mutagenicity and Carcinogenicity of Biological Reactive Intermediate's Derived A `Non-Genotoxic' Carcinogen; S.S. Lau, et al. Reactive Metabolites of 1,3-Butadiene: DNA and Hemoglobin Adduct Formation and Potential Roles in Carcinogenicity; A.A. Elfarra, et al. Chemistry and Biological Activity of Novel Selenium Containing Compounds; J.N.M. Commandeur, et al. Formation and Fate of Reactive Intermediates of Haloalkanes, Haloalkenes, and alpha-Haloacids; M.W. Anders. Short Communications. Session III. DNA Microarray Reveals Increased Expression of Thioredoxin Peroxidase in Thioredoxin-1 Transfected Cells and its Functional Consequences; B. Husbeck, et al. Reactive Nitrogen Species and Proteins: Biological Significance and Clinical Relevance; J.M. Souza, et al. Bicarbonate Enhances Nitration and Oxidation Reactionsin Biological Systems-Role of Reactive Oxygen and Nitrogen Species; B. Kalyanaraman, et al. Nitric Oxide and Peroxynitrite in Ozone-Induced Lung Injury; D.L. Laskin, et al. Antioxidant Reactions of Green Tea Catechins and Soy Isoflavones; D.C. Liebler, et al. Short Communications. Session IV. Chromosome Damage From Biological Reactive Intermediates of Benzene and 1,3-Butadiene in Leukemia; M.T. Smith. hOGG1 Gene Alterations in Human Clear Cell Carcinomas of the Kidney: Effect of Single Mutations in hOGG1 Gene on Substrate Specificity of the hOgg1 Protein; M. Audebert, et al. The Antitumor Agent Ecteinascidin 743: Characterization of its Covalent DNA Adducts and Chemical Stability; L.H. Hurley, M. Zewail-Foote. Design of DNA Damaging Agents that Hijack Transcription Factors and Block DNA Repair; J.M. Essigmann, et al. Short Communications. Session V. Are Blood-Brain Interfaces Efficient in Protecting the Brain From Reactive Molecules? J.-F. Ghersi-Egea, et al. The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers; A.H. Schinkel. Are Dopamine, Norepinephrine, and Serotonin precursors of Biologically Reactive Intermediates Involved in the Pathogenesis of Neurodegenerative Brain Disorders? G. Dryhurst. Serotonergic Neurotoxicity of Methylenedioxyamphetamine and Methylenedioxymetamphetamine; T.J. Monks, et al. Session VI. Caspase Cascades in Chemically-Induced Apoptosis; S.B. Bratton, G.M. Cohen. Spermatogenesis by Sisyphus: Proliferating Stem Germ Cells Fail to Repopulate the Testis After `Irreversible' Injury; K. Boekelheide, H.A. Schoenfeld. The Interaction of 1,4-Benzoquinone, A Bioreactive Intermediate of Benzene, With Three Proteins Essential for Differentiation? Maturation of the MoReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |