Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers

Author:   Morten Karsdal (CEO, Nordic Bioscience A/S, Herlev, Denmark)
Publisher:   Elsevier Science Publishing Co Inc
Edition:   2nd edition
ISBN:  

9780128170687


Pages:   434
Publication Date:   29 May 2019
Replaced By:   9780443156175
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers


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Overview

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease.

Full Product Details

Author:   Morten Karsdal (CEO, Nordic Bioscience A/S, Herlev, Denmark)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Weight:   0.660kg
ISBN:  

9780128170687


ISBN 10:   0128170689
Pages:   434
Publication Date:   29 May 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780443156175
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Type I collagen 2. Type II collagen 3. Type III collagen 4. Type IV collagen 5. Type V collagen 6. Type VI collagen 7. Type VII collagen 8. Type VIII collagen 9. Type IX collagen 10. Type X collagen 11. Type XI collagen 12. Type XII collagen 13. Type XIII collagen 14. Type XIV collagen 15. Type XV collagen 16. Type XVI collagen 17. Type XVII collagen 18. Type XVIII collagen 19. Type XIX collagen 20. Type XX collagen 21. Type XXI collagen 22. Type XXII collagen 23. Type XXIII collagen 24. Type XXIV collagen 25. Type XXV collagen 26. Type XXVI collagen 27. Type XXVII collagen 28. Type XXVIII collagen 29. Laminins 30. Elastin 31. The collagen chaperones 32. Collagen diseases 33. The signals of the extracellular matrix 34. The roles of collagens in cancer 35. Use of extracellular matrix biomarkers in clinical research 36. Common confounders when evaluating noninvasive protein biomarkers 37. Implementation of collagen biomarkers in the clinical setting

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Author Information

Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010. Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.

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