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OverviewThis text provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases-enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA. Full Product DetailsAuthor: David B. LombardPublisher: Springer Imprint: Springer Edition: 2001 ed. Dimensions: Width: 15.50cm , Height: 0.70cm , Length: 23.50cm Weight: 0.750kg ISBN: 9780792379843ISBN 10: 0792379845 Pages: 92 Publication Date: 30 November 2000 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1: The RecQ-family helicases.- 1. Helicases, topoisomerases, and disease.- 2. The RecQ-family helicases.- 3. Conclusions.- 2: Targeting the WRN locus in the mouse.- Abstract.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 3: Interaction of the BLM protein with Topo III alpha in somatic and meiotic cells.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 4: Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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