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OverviewBiochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA. Full Product DetailsAuthor: David B. LombardPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: Softcover reprint of the original 1st ed. 2001 Dimensions: Width: 15.50cm , Height: 0.50cm , Length: 23.50cm Weight: 0.185kg ISBN: 9781461355373ISBN 10: 1461355370 Pages: 92 Publication Date: 30 October 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1: The RecQ-family helicases.- 1. Helicases, topoisomerases, and disease.- 2. The RecQ-family helicases.- 3. Conclusions.- 2: Targeting the WRN locus in the mouse.- Abstract.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 3: Interaction of the BLM protein with Topo III alpha in somatic and meiotic cells.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 4: Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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